中国医药导刊
中國醫藥導刊
중국의약도간
Chinese Journal of Medical Guide
2015年
8期
815-817
,共3页
兰索拉唑%胶体果胶铋%盐酸伊托比利%吻合口溃疡%药物治疗
蘭索拉唑%膠體果膠鉍%鹽痠伊託比利%吻閤口潰瘍%藥物治療
란색랍서%효체과효필%염산이탁비리%문합구궤양%약물치료
Lansoprazole%Colloidal Bismuth%Itopride hydrochloride%Stomal ulcer%Drug therapy
目的：观察兰索拉唑胶囊联合胶体果胶铋颗粒和盐酸伊托比利胶囊治疗残胃吻合口溃疡的疗效。方法：将行胃大部分切除术后胃镜发现吻合口溃疡的患者82例纳入本研究。所有患者予以兰索拉唑胶囊30mg，每日1次，盐酸伊托比利50mg，每日3次，胶体果胶铋颗粒150mg，每日4次，疗程4～8周，4周后复查胃镜，溃疡未愈合者治疗8周后再次复查胃镜。观察治疗前，治疗后2周、4周和8周症状积分改变。结果：以兰索拉唑胶囊为主的三联疗法可明显改善吻合口溃疡的腹痛、腹胀症状，治疗2周症状积分明显下降（P＜0.05），治疗4周后溃疡能有效缩小，但4周和8周溃疡愈合率仅为9.76%和13.41%。结论：兰索拉唑胶囊联合胶体果胶铋颗粒和盐酸伊托比利胶囊治疗吻合口溃疡明显有效。
目的：觀察蘭索拉唑膠囊聯閤膠體果膠鉍顆粒和鹽痠伊託比利膠囊治療殘胃吻閤口潰瘍的療效。方法：將行胃大部分切除術後胃鏡髮現吻閤口潰瘍的患者82例納入本研究。所有患者予以蘭索拉唑膠囊30mg，每日1次，鹽痠伊託比利50mg，每日3次，膠體果膠鉍顆粒150mg，每日4次，療程4～8週，4週後複查胃鏡，潰瘍未愈閤者治療8週後再次複查胃鏡。觀察治療前，治療後2週、4週和8週癥狀積分改變。結果：以蘭索拉唑膠囊為主的三聯療法可明顯改善吻閤口潰瘍的腹痛、腹脹癥狀，治療2週癥狀積分明顯下降（P＜0.05），治療4週後潰瘍能有效縮小，但4週和8週潰瘍愈閤率僅為9.76%和13.41%。結論：蘭索拉唑膠囊聯閤膠體果膠鉍顆粒和鹽痠伊託比利膠囊治療吻閤口潰瘍明顯有效。
목적：관찰란색랍서효낭연합효체과효필과립화염산이탁비리효낭치료잔위문합구궤양적료효。방법：장행위대부분절제술후위경발현문합구궤양적환자82례납입본연구。소유환자여이란색랍서효낭30mg，매일1차，염산이탁비리50mg，매일3차，효체과효필과립150mg，매일4차，료정4～8주，4주후복사위경，궤양미유합자치료8주후재차복사위경。관찰치료전，치료후2주、4주화8주증상적분개변。결과：이란색랍서효낭위주적삼련요법가명현개선문합구궤양적복통、복창증상，치료2주증상적분명현하강（P＜0.05），치료4주후궤양능유효축소，단4주화8주궤양유합솔부위9.76%화13.41%。결론：란색랍서효낭연합효체과효필과립화염산이탁비리효낭치료문합구궤양명현유효。
Objective: To observe the effect of Lansoprazole Capsules combined Colloidal Bismuth Pectin Granules and itopride hydrochloride capsule in the treatment of stomal ulcer.Methods:82 cases of stomal ulcer after Subtotal Gastrectomy were included in this study.All patients given lansoprazole capsules 30mg,once per day,itopride hydrochloride 50mg,three times a day,colloidal bismuth pectin grain 150mg,four times daily.The treatment period are 4~8 weeks.After 4 weeks,the patients would be checked with the gastroscopy.If patients with ulcer were not be healed,which would be checked with the second gastroscopy after 8 weeks.Symptom score changes were observed before and after 2 weeks,4 weeks and 8 weeks treatment.Results:The triple therapy with lansoprazole capsule can markedly improve the abdominal pain and abdominal distension.Symptom scores decreased significantly after 2 weeks treatment (P<0.05).The size of ulcer was significantly reduced after 4 weeks treatment.But the cure rate of ulcer were 9.76% and 13.41% in 4weeks and 8weeks Respectively.Conclusion:Lansoprazole capsules combined with colloidal bismuth pectin particles and itopride hydrochloride capsule have obvious effect in the treatment of stomal ulcer.
