CAJ | 학술논문

目的：对比分析应用植入性缓释氟尿嘧啶同步放化疗与顺铂方案同步放化疗治疗中晚期宫颈癌患者的疗效与毒副作用。方法选择2013年1月－2014年7月在新疆医科大学附属肿瘤医院收治的初治宫颈癌患者共80例，临床分期为Ⅱb～Ⅲb 期，按治疗方法不同分试验组40例（氟尿嘧啶瘤内植入区域化疗配合根治性放疗组），对照组40例（顺铂静脉周疗配合根治性放疗组）。对两组患者的近期疗效及毒副反应进行对比分析。结果试验组 CR 为22例，PR 为13例，NC 和 PD 为5例。对照组 CR 为19例，PR 为14例，NC 和 PD 为7例。试验组和对照组有效率分别为88％（35／40）、83％（32／40），两组比较差异无统计学意义。3级以上的急性反应中，试验组出现骨髓抑制6例，消化道反应3例；对照组出现骨髓抑制17例，消化道反应5例，两组间骨髓抑制差异有统计学意义（P ＜0．05）。结论植入性缓释氟尿嘧啶同步放化疗与顺铂周疗疗效相当，毒副反应较小。
목적：대비분석응용식입성완석불뇨밀정동보방화료여순박방안동보방화료치료중만기궁경암환자적료효여독부작용。방법선택2013년1월－2014년7월재신강의과대학부속종류의원수치적초치궁경암환자공80례，림상분기위Ⅱb～Ⅲb 기，안치료방법불동분시험조40례（불뇨밀정류내식입구역화료배합근치성방료조），대조조40례（순박정맥주료배합근치성방료조）。대량조환자적근기료효급독부반응진행대비분석。결과시험조 CR 위22례，PR 위13례，NC 화 PD 위5례。대조조 CR 위19례，PR 위14례，NC 화 PD 위7례。시험조화대조조유효솔분별위88％（35／40）、83％（32／40），량조비교차이무통계학의의。3급이상적급성반응중，시험조출현골수억제6례，소화도반응3례；대조조출현골수억제17례，소화도반응5례，량조간골수억제차이유통계학의의（P ＜0．05）。결론식입성완석불뇨밀정동보방화료여순박주료료효상당，독부반응교소。
Objective To compare the treatment effects and side effects between local chemotherapy match radiotherapy and cisplatin match radiotherapy for cervical cancer.Methods Totally 80 patients with pri-mary cervical in Xinjiang Tumor Hospital were selected from January 2013 to July 2014.who were divided in two groups:experimental (A)group 40 patients (local chemotherapy match radiotherapy),control (B) group(cisplatin match radiotherapy).Contrastive analysis were investigated on the short- term efficacy and adverse reaction in the two groups.Results In the experimental (A)group,CR were 22,PR were13, NC and PD were 5 respectively.In the control (B)group,CR were 22,PR were13,NC and PD were 5, respectively.The local control rate (CR+PR)in two groups were 88% and 83%,There was no difference in two groups.,While the side effects had significant difference in the two groups (P <0.05).Conclusion The local control rate between two groups was not different,but the side effects of local chemotherapy match radiotherapy was less.