CAJ | 학술논문

目的：探讨丹红注射液对严重脓毒症患者凝血功能及血乳酸的影响。方法：选择重症医学科收治的严重脓毒症患者100例，随机分为治疗组（n ＝52）和对照组（n ＝48），2组患者入院开始即给予充分的液体复苏、积极的抗感染治疗，必要时予血管活性药物、选择性的给予氢化可的松、呼吸机辅助通气等支持治疗，治疗组加用丹红注射液40 mL 静脉滴注，1次／d。2组患者在入院时及入院第7天时监测急性生理学及慢性健康状况评分（APACHE Ⅱ评分）、凝血指标及血乳酸水平，并监测患者28 d 死亡率。结果：2组患者入院第7天的凝血指标、血乳酸（Blood Lactic Acid，BLA）及 APACHE Ⅱ评分比较均有统计学意义（P ＜0．05）；患者28天死亡率治疗组比对照组低，但差异无统计学意义（P ＞0．05）。结论：丹红注射液可改善严重脓毒症患者凝血状态及低灌注缺氧代谢。
목적：탐토단홍주사액대엄중농독증환자응혈공능급혈유산적영향。방법：선택중증의학과수치적엄중농독증환자100례，수궤분위치료조（n ＝52）화대조조（n ＝48），2조환자입원개시즉급여충분적액체복소、적겁적항감염치료，필요시여혈관활성약물、선택성적급여경화가적송、호흡궤보조통기등지지치료，치료조가용단홍주사액40 mL 정맥적주，1차／d。2조환자재입원시급입원제7천시감측급성생이학급만성건강상황평분（APACHE Ⅱ평분）、응혈지표급혈유산수평，병감측환자28 d 사망솔。결과：2조환자입원제7천적응혈지표、혈유산（Blood Lactic Acid，BLA）급 APACHE Ⅱ평분비교균유통계학의의（P ＜0．05）；환자28천사망솔치료조비대조조저，단차이무통계학의의（P ＞0．05）。결론：단홍주사액가개선엄중농독증환자응혈상태급저관주결양대사。
Objective:To observe the effect of Danhong injection on blood coagulation function and blood lactic acid in patients with severe sepsis.Methods:A hundred patients with severe sepsis from the Intesive Care Unite were randomly classified into treat-ment group(n =52)and control group(n =48).Patients in both groups were treated with fluid resuscitation,anti infection drugs at admission and given the vasoactive drug,hydrocortisone and mechanical ventilation support when necessary.The treatment group was treated with Danhong injection intravenous infusion of 40 mL once a day.APACHE Ⅱscore,blood coagulation indexes and blood lactic acid were measured at admission and the seventh day of hospitalization.The mortality was monitored at the 28th day of hospitalization.Results:The blood coagulation indexes,blood lactic acid and APACHE Ⅱscore of the treatment group and the control group were of significant difference at the seventh day(P <0.05).The 28d mortality of the treatment group was lower than the control group,but the difference were not of statistically significance(P >0.05).Conclusion:Danhong injection can improve the blood coagulation state and decrease perfusion hypoxia in severe sepsis patients.