CAJ | 학술논문

目的：观察宫腔内人工授精促排卵周期中使用促性腺激素释放激素激动剂（ GnRha）诱导卵泡成熟的疗效，探讨促性腺激素释放激素激动剂（ GnRha）促进卵泡成熟对腔内人工授精临床结局的影响。方法选择2013年4月至2015年4月我院进行宫腔内人工授精促排卵的100例PCOS患者作为研究对象，将其随机分为应用促性腺激素释放激素激动剂（GnRha）诱导卵泡成熟为实验组（n＝50）和应用绒毛膜促性腺激素（hCG）诱导卵泡成熟为对照组（n＝50）。对照组患者在注射hCG后24～36小时内进行宫腔内人工授精，实验组患者在注射GnRHa后的24～36小时内进行宫腔内人工授精。比较对照组和观察组的排卵率、妊娠率及流产率。结果对照组和实验组患者的排卵率、妊娠率、流产率均未出现明显的差异，P＞0．05，差异不具有统计学意义。结论在宫腔内人工授精促排卵周期中使用GnRHA能够有效诱导卵泡成熟，其与hCG的促排卵效果接近，可替代hCG进行诱导排卵。
목적：관찰궁강내인공수정촉배란주기중사용촉성선격소석방격소격동제（ GnRha）유도란포성숙적료효，탐토촉성선격소석방격소격동제（ GnRha）촉진란포성숙대강내인공수정림상결국적영향。방법선택2013년4월지2015년4월아원진행궁강내인공수정촉배란적100례PCOS환자작위연구대상，장기수궤분위응용촉성선격소석방격소격동제（GnRha）유도란포성숙위실험조（n＝50）화응용융모막촉성선격소（hCG）유도란포성숙위대조조（n＝50）。대조조환자재주사hCG후24～36소시내진행궁강내인공수정，실험조환자재주사GnRHa후적24～36소시내진행궁강내인공수정。비교대조조화관찰조적배란솔、임신솔급유산솔。결과대조조화실험조환자적배란솔、임신솔、유산솔균미출현명현적차이，P＞0．05，차이불구유통계학의의。결론재궁강내인공수정촉배란주기중사용GnRHA능구유효유도란포성숙，기여hCG적촉배란효과접근，가체대hCG진행유도배란。
Objective To observe the curative effect of using GnRhato inducematurationof follicle in the intrauterine inseminationovulationcycle, explore the influence of GnRha on clinical outcomes of intrauterine inseminationovulation.Methods 100cases ofpatients received intrauterine inseminationovulation in our hospital during April2013 and April2015 were selected as researchobject, they were randomly divided intoexperimental group (applied GnRha for induction offollicular maturation,n=50) and control group (applied HCGforinduction offollicular maturation, n =50 ) .The patients of control groupreceivedintrauterine insemination within24 to 36hoursafter HCG injection,the patients in the experimental groupreceivedintrauterine insemination within24 to 36hoursafter injection of GnRha.Ovulation rate,pregnancy rate andabortion rate of the two groups were compared. Results The ovulation rate,pregnancy rate and abortion rateshowed no obviousdifference between controlgroup and the experimental group(P>0.05).Conclusions In intrauterine inseminationovulationcycle usingGnRhacan effectively inducefollicular maturation, andclose totheovulationeffect of HCG, it can substitute HCG forovulation induction.