CAJ | 학술논문

目的：探讨成纤维生长因子受体2（FGFR2）rs2981582基因多态性与新疆地区维吾尔族、汉族乳腺癌易感性的相关性。方法应用聚合酶链反应-限制性片段多态性（PCR-RFLP）检测192例维吾尔族女性乳腺癌患者（病例组）、200例健康者（对照组）及254例汉族女性乳腺癌患者（病例组）及200例健康者（对照组）FGFR2 rs2981582位点多态性，分析该位点多态性与新疆维吾尔族、汉族乳腺癌易感性的关系。结果维吾尔族病例组与对照组基因型分布差异有统计学意义（P ＝0．000）。汉族病例组与对照组基因型分布差异无统计学意义（P ＝0．110）。维吾尔族人群 FGFR2基因 rs2981582多态性与乳腺癌易感性相关（CT vs CC：OR ＝2．375，95％ CI ＝1．502～3．755），汉族人群 FGFR2基因 rs2981582多态性亦与乳腺癌易感性相关（TT vs CC：OR ＝1．735，95％ CI＝1．016～2．963；T vs C：OR ＝1．327，95％ CI ＝1．019～1．728）。结论新疆地区维吾尔族及汉族人群 FGFR2基因 rs2981582位点多态性均表现出与乳腺癌易感性相关。
목적：탐토성섬유생장인자수체2（FGFR2）rs2981582기인다태성여신강지구유오이족、한족유선암역감성적상관성。방법응용취합매련반응-한제성편단다태성（PCR-RFLP）검측192례유오이족녀성유선암환자（병례조）、200례건강자（대조조）급254례한족녀성유선암환자（병례조）급200례건강자（대조조）FGFR2 rs2981582위점다태성，분석해위점다태성여신강유오이족、한족유선암역감성적관계。결과유오이족병례조여대조조기인형분포차이유통계학의의（P ＝0．000）。한족병례조여대조조기인형분포차이무통계학의의（P ＝0．110）。유오이족인군 FGFR2기인 rs2981582다태성여유선암역감성상관（CT vs CC：OR ＝2．375，95％ CI ＝1．502～3．755），한족인군 FGFR2기인 rs2981582다태성역여유선암역감성상관（TT vs CC：OR ＝1．735，95％ CI＝1．016～2．963；T vs C：OR ＝1．327，95％ CI ＝1．019～1．728）。결론신강지구유오이족급한족인군 FGFR2기인 rs2981582위점다태성균표현출여유선암역감성상관。
Objective To investigate the association between rs2981582 in FGFR2 gene and the susceptibility of breast cancer in Uyghur and Han population.Methods The rs2981582 polymorphism of 192 Uyghur breast cancer patients,200 Uyghur healthy person,254 Han breast cancer patients and 200 Han healthy person were detected by PCR-RFLP.The relationship between the SNP polymorphism and susceptibility of breast cancer was analyzed.Results In the Uygur group,the difference of genotypes distribution between the breast cancer patients and healthy person was statistically significant (P =0.000).The difference of genotypes distribution between the breast cancer patients and healthy person in Han,was not significantly (P =0.110).In the Uygur population,the rs2981582 polymorphism is associated with the susceptibility of breast cancer in Uygur (CT vs CC:OR =2.375,95% CI =1.502~3.755)and Han (TT vs CC:OR =1.735,95% CI =1.016~2.963;T vs C:OR =1.327,95% CI =1.019~1.728),respectively.Conclusion The rs2981582 polymorphism is significantly associated with the susceptibility of breast cancer in Uyghur and Han in Xinjiang.