中国医药导报
中國醫藥導報
중국의약도보
China Medical Herald
2015年
26期
54-57
,共4页
血压变异性%冠状动脉病变%原发性高血压%血压昼夜节律%动态血压
血壓變異性%冠狀動脈病變%原髮性高血壓%血壓晝夜節律%動態血壓
혈압변이성%관상동맥병변%원발성고혈압%혈압주야절률%동태혈압
Blood pressure variability%Coronary artery disease%Essential hypertension%Circadian rhythm%Ambulatory blood pressure
目的：探讨原发性高血压患者血压变异性与冠状动脉病变程度的相关性。方法选择2013年1月~2014年11月于成都市第五人民医院诊治的216例原发性高血压患者,根据冠状动脉造影结果,分为合并冠脉病变组118例和单纯高血压组98例。合并冠脉病变组根据冠状动脉Gensini评分分为轻度组、中度组和重度组,分析动态血压、心肌缺血总负荷(TIB)及冠状动脉Gensini评分的关系。结果合并冠脉病变组24 h平均收缩压(24 h SBP)、日间平均收缩压(dSBP)、夜间平均收缩压(nSBP)、24 h收缩压变异系数(24 h SCV)、24 h舒张压变异系数(24 h DCV)、日间收缩压变异系数(dSCV)、夜间收缩压变异系数(nSCV)、日间舒张压变异系数(dDCV)、夜间舒张压变异系数(nDCV)均明显高于单纯高血压组(P<0.05)。轻度组、中度组和重度组24 h SCV、24 h DCV、dSCV、nSCV、TIB差异均有统计学意义(P<0.05)。24 h SCV、dSCV均与TIB呈正相关(P<0.05),24 h SCV、dSCV、nSCV均与冠状动脉病变Gensini评分呈正相关(P<0.05)。多元线性回归分析显示,24 h SCV、dSCV、nSCV与冠状动脉病变程度独立相关(P<0.05)。结论血压变异性随冠状动脉病变程度及TIB增加而升高；24 h SCV、dSCV、nSCV与冠状动脉病变程度独立相关。
目的：探討原髮性高血壓患者血壓變異性與冠狀動脈病變程度的相關性。方法選擇2013年1月~2014年11月于成都市第五人民醫院診治的216例原髮性高血壓患者,根據冠狀動脈造影結果,分為閤併冠脈病變組118例和單純高血壓組98例。閤併冠脈病變組根據冠狀動脈Gensini評分分為輕度組、中度組和重度組,分析動態血壓、心肌缺血總負荷(TIB)及冠狀動脈Gensini評分的關繫。結果閤併冠脈病變組24 h平均收縮壓(24 h SBP)、日間平均收縮壓(dSBP)、夜間平均收縮壓(nSBP)、24 h收縮壓變異繫數(24 h SCV)、24 h舒張壓變異繫數(24 h DCV)、日間收縮壓變異繫數(dSCV)、夜間收縮壓變異繫數(nSCV)、日間舒張壓變異繫數(dDCV)、夜間舒張壓變異繫數(nDCV)均明顯高于單純高血壓組(P<0.05)。輕度組、中度組和重度組24 h SCV、24 h DCV、dSCV、nSCV、TIB差異均有統計學意義(P<0.05)。24 h SCV、dSCV均與TIB呈正相關(P<0.05),24 h SCV、dSCV、nSCV均與冠狀動脈病變Gensini評分呈正相關(P<0.05)。多元線性迴歸分析顯示,24 h SCV、dSCV、nSCV與冠狀動脈病變程度獨立相關(P<0.05)。結論血壓變異性隨冠狀動脈病變程度及TIB增加而升高；24 h SCV、dSCV、nSCV與冠狀動脈病變程度獨立相關。
목적：탐토원발성고혈압환자혈압변이성여관상동맥병변정도적상관성。방법선택2013년1월~2014년11월우성도시제오인민의원진치적216례원발성고혈압환자,근거관상동맥조영결과,분위합병관맥병변조118례화단순고혈압조98례。합병관맥병변조근거관상동맥Gensini평분분위경도조、중도조화중도조,분석동태혈압、심기결혈총부하(TIB)급관상동맥Gensini평분적관계。결과합병관맥병변조24 h평균수축압(24 h SBP)、일간평균수축압(dSBP)、야간평균수축압(nSBP)、24 h수축압변이계수(24 h SCV)、24 h서장압변이계수(24 h DCV)、일간수축압변이계수(dSCV)、야간수축압변이계수(nSCV)、일간서장압변이계수(dDCV)、야간서장압변이계수(nDCV)균명현고우단순고혈압조(P<0.05)。경도조、중도조화중도조24 h SCV、24 h DCV、dSCV、nSCV、TIB차이균유통계학의의(P<0.05)。24 h SCV、dSCV균여TIB정정상관(P<0.05),24 h SCV、dSCV、nSCV균여관상동맥병변Gensini평분정정상관(P<0.05)。다원선성회귀분석현시,24 h SCV、dSCV、nSCV여관상동맥병변정도독립상관(P<0.05)。결론혈압변이성수관상동맥병변정도급TIB증가이승고；24 h SCV、dSCV、nSCV여관상동맥병변정도독립상관。
Objective To investigate the relationship between primary blood pressure variability and extent of coronary artery disease in patients with hypertension. Methods From January 2013 to November 2014, in the Fifth People's Hospital of Chengdu City 216 cases of patients with essential hypertension, according to the results of coronary angiog-raphy, were divided into the combined with coronary artery disease group (118 cases) and hypertension group (98 cas-es). According to Gensini score, patients in the combined with coronary artery disease group were divided into the mild, moderate and severe groups. The relationships among ambulatory blood pressure, total ischemia burden (TIB) and coro-nary artery Gensini score were analyzed. Results Combined with coronary artery disease group, 24 h SBP, dSBP, nSBP, 24 h SCV, 24 h DCV, dSCV, nSCV, dDCV, nDCV were significantly higher than those of hypertension group (P <0.05). In mild, moderate and severe groups, differences in 24 h SCV, 24 h DCV, dSCV, nSCV and TIB had statistically significant (P<0.05). 24 h SCV, dSCV were positively associated with TIB (P<0.05). 24 h SCV, dSCV, nSCV were positively correlated with Gensini score of coronary artery disease (P< 0.05). Results of multivariate linear regression analysis showed that 24 h SCV, dSCV, nSCV independently associated with coronary artery disease (P< 0.05). Con-clusion Blood pressure variability increases with the degree of coronary artery disease and elevates TIB. 24 h SCV, dSCV, nSCV independently associated with coronary artery disease.
