CAJ | 학술논문

目的：探讨FPG对T2DM患者红细胞（RBC）变形及免疫功能的影响。方法利用新型显微成像与动静态图像分析系统对单个活态RBC形态及膜弹性进行测量，运用酵母菌花环试验对RBC的免疫功能进行测定。测量正常（NC ）组和 T2DM 7个FPG水平组RBC的形态、膜弹性及免疫功能参数。结果 T2DM各组圆度因子、膜弹性参数及RBC免疫复合物结合花环率（RBC‐ICRR）均高于NC组，RBC膜上C3b受体结合花环率（RBC‐C3bRR）低于NC组（P＜0.05）；随FPG上升，圆度因子、膜弹性参数及RBC‐ICRR增加，而RBC‐C3bRR减小，在FPG较低（FPG＜9.0 mmol／L）的非相邻两组间差异有统计学意义（ P＜0.05）。结论随FPG上升，RBC变形及免疫功能减弱。
목적：탐토FPG대T2DM환자홍세포（RBC）변형급면역공능적영향。방법이용신형현미성상여동정태도상분석계통대단개활태RBC형태급막탄성진행측량，운용효모균화배시험대RBC적면역공능진행측정。측량정상（NC ）조화 T2DM 7개FPG수평조RBC적형태、막탄성급면역공능삼수。결과 T2DM각조원도인자、막탄성삼수급RBC면역복합물결합화배솔（RBC‐ICRR）균고우NC조，RBC막상C3b수체결합화배솔（RBC‐C3bRR）저우NC조（P＜0.05）；수FPG상승，원도인자、막탄성삼수급RBC‐ICRR증가，이RBC‐C3bRR감소，재FPG교저（FPG＜9.0 mmol／L）적비상린량조간차이유통계학의의（ P＜0.05）。결론수FPG상승，RBC변형급면역공능감약。
Objective To explore the effect of fasting plasma glucose (FPG)level on red blood cell (RBC) deformability and immune function in patients with type 2 diabetes mellitus(T2DM ). Methods The morphological structure and membrane elasticity of single living RBC were analyzed by novel microscopic imaging technology and static and dynamic image analysis system. Immune function of RBC was detected by yeast rosette test. Morphological structure ,membrane elasticity and immune function parameters of RBC were determined respectively in NC group and seven T 2DM groups of different FPG levels. Results Roundness factors ,membrane elasticity parameters and RBC immune complexes rosette rate (RBC‐ICRR) in T2DM groups were all higher than those in NC group and RBC C3b receptor rosette rates (RBC‐C3bRR ) were lower in T2DM groups than those in NC group. The differences were statistically significant (P<0.05). With rising of FPG level ,RBC‐ICRR ,roundness factors and membrane elasticity parameters were all increased and RBC‐C3bRR was reduced. The differences between two non‐adjacent groups of lower FPG level (FPG < 9.0 mmol/L) were statistically significant (P< 0.05). Conclusion With increasing of FPG level ,deformability and immune function of RBC both decline g radually.