CAJ | 학술논문

目的：探讨放化疗联合靶向治疗晚期胆道恶性肿瘤的临床效果。方法选择郑州大学第一附属医院2013年5月至2014年5月期间收治的126例晚期胆道恶性肿瘤患者的临床资料进行回顾性分析，按治疗方法不同分为治疗组（n ＝64）和对照组（n ＝62）。对照组采用放化疗，而治疗组则采用放化疗联合靶向药物治疗，观察并比较两种治疗方法下的临床总有效率和毒副反应率差异。结果治疗组病情完全缓解13例，部分缓解28例，病情稳定19例，疾病进展4例，临床总有效率为64．06％（41／64）；治疗后共15例产生毒副作用，毒副反应率为23．44％（15／64）。观察组临床总有效率较对照组高，毒副反应发生率较对照组低，差异有统计学意义（P ＜0．05）。结论放化疗联合靶向药物应用于晚期胆道恶性肿瘤的治疗中可有效提高近期疗效，降低毒副反应率，其效果显著优于单纯放化疗，值得在临床上推广使用。
목적：탐토방화료연합파향치료만기담도악성종류적림상효과。방법선택정주대학제일부속의원2013년5월지2014년5월기간수치적126례만기담도악성종류환자적림상자료진행회고성분석，안치료방법불동분위치료조（n ＝64）화대조조（n ＝62）。대조조채용방화료，이치료조칙채용방화료연합파향약물치료，관찰병비교량충치료방법하적림상총유효솔화독부반응솔차이。결과치료조병정완전완해13례，부분완해28례，병정은정19례，질병진전4례，림상총유효솔위64．06％（41／64）；치료후공15례산생독부작용，독부반응솔위23．44％（15／64）。관찰조림상총유효솔교대조조고，독부반응발생솔교대조조저，차이유통계학의의（P ＜0．05）。결론방화료연합파향약물응용우만기담도악성종류적치료중가유효제고근기료효，강저독부반응솔，기효과현저우우단순방화료，치득재림상상추엄사용。
Objective To explore the clinical effect of radio -chemotherapy combined with targeted therapy on advanced bile duct cancer.Methods 126 patients with advanced bile duct cancer from May of 2013 to May of 2014 in the First Affiliated Hos-pital of Zhengzhou University were selected for retrospective analysis and divided into the treatment group(n =64)and the control group(n =62)according to different treatment methods.The control group were treated with radio -chemotherapy while the treat-ment group was treated with radio -chemotherapy combined with targeted therapy.The clinical total effective rates and adverse reaction rates of two groups were observed and compared.Results In the treatment group,there were 13 cases of complete re-mission,28 cases of partial remission,19 cases of stable disease and 4 cases of disease progression;the clinical total effective rate was 64.06%(41 /64).And there were 15 cases of side effects with the occurrence rate of side toxic reaction for 23.44%(15 /64).Compared with control group,the clinical total effective rate of treatment group was higher and the occurrence rate of side toxic reaction was lower,and the differences were statistically significant(P <0.05).Conclusion In the treatment of ad-vanced bile duct cancer,Radio -chemotherapy combined with targeted therapy can effectively improve the efficacy and reduce the adverse reaction.Its effect is better than simple chemotherapy.It deserves the clinical expansion.