CAJ | 학술논문

目的：分析降钙素原( PCT)在儿童全身炎症反应综合征诊疗中的临床价值,探讨PCT在儿童全身炎症反应治疗中的指导作用。方法177例全身炎症反应综合征患儿随机分为常规组(89例)和 PCT组(88例)。常规组参照国家治疗指南标准使用抗菌药物治疗；PCT组按照PCT水平决定是否使用抗菌药物,血清PCT≥0．50 ng/mL,使用抗菌药物治疗；PCT<0．50 ng/mL不使用抗菌药物。比较两组患儿的炎症标志物水平、抗菌药物使用时间及住院时间。结果 PCT组治疗前后的炎症指标与常规组差异无统计学意义(P>0．05)；但PCT组的抗菌药物使用率、使用时间及住院时间明显短于常规组,差异有统计学意义(P<0．05)。结论动态监测患儿PCT水平,对于减少抗菌药物使用及缩短住院时间具有重要的临床指导意义。
목적：분석강개소원( PCT)재인동전신염증반응종합정진료중적림상개치,탐토PCT재인동전신염증반응치료중적지도작용。방법177례전신염증반응종합정환인수궤분위상규조(89례)화 PCT조(88례)。상규조삼조국가치료지남표준사용항균약물치료；PCT조안조PCT수평결정시부사용항균약물,혈청PCT≥0．50 ng/mL,사용항균약물치료；PCT<0．50 ng/mL불사용항균약물。비교량조환인적염증표지물수평、항균약물사용시간급주원시간。결과 PCT조치료전후적염증지표여상규조차이무통계학의의(P>0．05)；단PCT조적항균약물사용솔、사용시간급주원시간명현단우상규조,차이유통계학의의(P<0．05)。결론동태감측환인PCT수평,대우감소항균약물사용급축단주원시간구유중요적림상지도의의。
Objective To assess the clinical value of procalcitonin ( PCT) in the treatment of systematic inflammatory response syn-drome ( SIRS) among children. Methods A total of 177 children with SIRS in our ward were divided into routine group and PCT-guided treatment group ( PCT group) randomly. The children in routine group were treated with antibiotics according to the guideline for antibiotics use. Meanwhile, whether to use antibiotics of the children in PCT group was decided by serum level of PCT. Antibiotics were used when PCT level was more than 0. 50 ng/mL and antibiotics were not used when PCT level was less than 0. 50 ng/mL. Inflammatory markers, time of an-tibiotics use and inpatient days were compared between the two groups. Results There was no significant difference in white blood cell, C reaction protein(CRP) and clinical effects of patients in PCT group after antibiotics use between PCT group and routine group(P>0. 05). However, days of antibiotics use and inpatient stay in PCT group were significant shorter than in routine group(P<0. 05). Conclusion Mo-nitoring serum lever of PCT is of important clinical significance in reducing the use of antibiotics and shortening the course of treatment.