CAJ | 학술논문

氧化应激水平可以通过抗氧化酶系水平、非酶系抗氧化水平及氧化产物水平检测。在糖尿病前期患者体内存在高氧化应激状态，随着糖代谢紊乱加重，体内自由基生成增加，抗氧化能力下降，氧化应激水平升高，氧化与抗氧化失衡。在2型糖尿病患者中，随着糖尿病的病程延长，氧化应激水平随之升高，且胰岛β细胞功能下降，胰岛素抵抗增加。动脉粥样硬化的发生发展与氧化应激有密切关系，冠心病患者体内已存在氧化应激，且机体抗氧化能力减弱。在冠心病合并糖尿病患者中，随着病情进展，氧化损伤程度呈逐渐加重趋势。本文就不同糖代谢状态冠心病患者氧化应激的相关性研究进展进行综述。
양화응격수평가이통과항양화매계수평、비매계항양화수평급양화산물수평검측。재당뇨병전기환자체내존재고양화응격상태，수착당대사문란가중，체내자유기생성증가，항양화능력하강，양화응격수평승고，양화여항양화실형。재2형당뇨병환자중，수착당뇨병적병정연장，양화응격수평수지승고，차이도β세포공능하강，이도소저항증가。동맥죽양경화적발생발전여양화응격유밀절관계，관심병환자체내이존재양화응격，차궤체항양화능력감약。재관심병합병당뇨병환자중，수착병정진전，양화손상정도정축점가중추세。본문취불동당대사상태관심병환자양화응격적상관성연구진전진행종술。
The level of oxidative stress can be tested by antioxidant enzyme system level, antioxidant non-enzyme dsystem level and oxidation products. High oxidative stress state exists in people who have pre-diabetes, and with the sugar metabolic disorder exacerbating, free radicals generation increased, the ability of anti-oxidation dropped, the lev-el of oxidative stress raised, oxidation and antioxidant imbalanced. In patients with type 2 diabetes, with the course of diabetes being longer, the level of oxidative stress will increase, and else the function of the islet beta cell dropped, in-sulin resistance increased. The development of atherosclerosis has deeply related with oxidative stress. There is oxida-tive stress in coronary heart disease patients, and the body's antioxidant capacity reduced. In patients with coronary heart disease and diabetes mellitus, as the disease progresses, the degree of oxidative damage also shows a trend of in-crease gradually. In this paper, the research progress of the correlation of oxidative stress of different glucose metabolism status in patients with coronary heart disease will be reviewed.