中国医药导报
中國醫藥導報
중국의약도보
China Medical Herald
2015年
26期
34-38
,共5页
NADPH氧化酶%心血管疾病%氧化应激%抗氧化治疗
NADPH氧化酶%心血管疾病%氧化應激%抗氧化治療
NADPH양화매%심혈관질병%양화응격%항양화치료
NADPH oxidase%Cardiovascular disease%Oxidative stress%Antioxidant therapy
NADPH氧化酶是唯一一类以生成活性氧类物质为主要功能的酶类，目前共发现7种亚型，心血管系统表达其中4种。 NADPH氧化酶参与心脏和血管生理与病理过程的调节，如细胞增殖、迁移、细胞肥大、凋亡和细胞外基质重构等。本文较系统的综述NADPH氧化酶在常见心血管疾病包括心力衰竭、冠心病、高血压病和心律失常中的表达与作用，以期为临床抗氧化治疗提供帮助。
NADPH氧化酶是唯一一類以生成活性氧類物質為主要功能的酶類，目前共髮現7種亞型，心血管繫統錶達其中4種。 NADPH氧化酶參與心髒和血管生理與病理過程的調節，如細胞增殖、遷移、細胞肥大、凋亡和細胞外基質重構等。本文較繫統的綜述NADPH氧化酶在常見心血管疾病包括心力衰竭、冠心病、高血壓病和心律失常中的錶達與作用，以期為臨床抗氧化治療提供幫助。
NADPH양화매시유일일류이생성활성양류물질위주요공능적매류，목전공발현7충아형，심혈관계통표체기중4충。 NADPH양화매삼여심장화혈관생리여병리과정적조절，여세포증식、천이、세포비대、조망화세포외기질중구등。본문교계통적종술NADPH양화매재상견심혈관질병포괄심력쇠갈、관심병、고혈압병화심률실상중적표체여작용，이기위림상항양화치료제공방조。
The NADPH oxidase (Nox) is the only known enzyme with the sole function to produce reactive oxygen species (ROS). Seven family members have been identified, and four of them are expressed in the cardiovascular system. Nox perform an important role in regulation of the physical and pathological process in cardiovascular system, such as cell proliferation, migration, cell hypertrophy, apoptosis and remodeling of extracellular matrix. Here we review the recent progress in the expression and function of Nox in common cardiovascular diseases, including heart failure, coronary heart disease, hypertension and cardiac arrhythmia, thus to provide some help for clinical antioxidant therapy.
