CAJ | 학술논문

目的：探讨来曲唑个体化促排卵治疗对克罗米芬抵抗多囊卵巢综合征（ PCOS）不孕患者的疗效。方法52例克罗米芬抵抗PCOS不孕确诊患者，严密监测卵泡发育下，给予来曲唑个体化延长治疗，观察来曲唑每周期用药量、优势卵泡数、人绒毛膜促性腺激素（ hCG）注射日及子宫内膜厚度、排卵率和妊娠率，分析临床疗效。结果52例患者来曲唑个体化延长促排卵治疗共102个周期，来曲唑平均周期用药量（42．73±13．73）mg〔（17．09±5．49）片〕；排卵率91．17％，妊娠率为65．38％；无卵巢过度刺激综合征发生。结论对克罗米芬抵抗PCOS不孕患者，在严密监测下，来曲唑个体化延长治疗可以取得安全有效的促排卵和妊娠结果。
목적：탐토래곡서개체화촉배란치료대극라미분저항다낭란소종합정（ PCOS）불잉환자적료효。방법52례극라미분저항PCOS불잉학진환자，엄밀감측란포발육하，급여래곡서개체화연장치료，관찰래곡서매주기용약량、우세란포수、인융모막촉성선격소（ hCG）주사일급자궁내막후도、배란솔화임신솔，분석림상료효。결과52례환자래곡서개체화연장촉배란치료공102개주기，래곡서평균주기용약량（42．73±13．73）mg〔（17．09±5．49）편〕；배란솔91．17％，임신솔위65．38％；무란소과도자격종합정발생。결론대극라미분저항PCOS불잉환자，재엄밀감측하，래곡서개체화연장치료가이취득안전유효적촉배란화임신결과。
Objective To investigate the clinical efficacy of individualized letrozole therapy for polycystic ovary syn -drome ( PCOS) patients resistant to clomiphene .Methods A total of 52 PCOS patients resistant to clomiphene were en-rolled in the current study .They were administrated with individualized letrozole therapy , while their follicle growth was strictly monitored.Then, the following information was recorded to analyze clinical efficacy:the weekly dosage of letro-zole, the number of dominant follicles , hCG injection date , endometrial thickness , and the rates of ovulation and preg-nancy.Results The individualized letrozole therapy was applied for 102 cycles.The average dosage of letrozole was (42.73 ±13.73) mg [(17.09 ±5.49) tablets].The rates of ovulation and pregnancy were 91.17% and 65.38%, respectively .No ovarian hyperstimulation syndrome was reported .Conclusion Individualized letrozole therapy can ef-fectively improve the rates of ovulation and pregnancy for PCOS patients resistant to clomiphene under strictly monitoring conditions.