CAJ | 학술논문

目的：探讨坎地沙坦对阿尔茨海默病（ AD）大鼠认知功能的影响及机制。方法采用侧脑室注射β－淀粉样蛋白（ Aβ）建立大鼠AD模型，利用Morris水迷宫检测坎地沙坦对大鼠的学习记忆的影响；通过免疫印迹方法检测大鼠海马区神经元型一氧化氮合酶（ nNOS）表达水平的变化。结果 Morris水迷宫结果显示给予坎地沙坦的AD模型大鼠找到平台的时间明显缩短，说明坎地沙坦可以明显改善AD大鼠的学习记忆能力；免疫印迹法显示坎地沙坦可以明显降低Aβ介导的nNOS磷酸化水平的升高。结论坎地沙坦可以改善AD大鼠认知功能，这可能与其降低Aβ介导的nNOS磷酸化水平的升高有关。
목적：탐토감지사탄대아이자해묵병（ AD）대서인지공능적영향급궤제。방법채용측뇌실주사β－정분양단백（ Aβ）건립대서AD모형，이용Morris수미궁검측감지사탄대대서적학습기억적영향；통과면역인적방법검측대서해마구신경원형일양화담합매（ nNOS）표체수평적변화。결과 Morris수미궁결과현시급여감지사탄적AD모형대서조도평태적시간명현축단，설명감지사탄가이명현개선AD대서적학습기억능력；면역인적법현시감지사탄가이명현강저Aβ개도적nNOS린산화수평적승고。결론감지사탄가이개선AD대서인지공능，저가능여기강저Aβ개도적nNOS린산화수평적승고유관。
Objective To investigate the effect of candesartan on the cognitive function using a rat model of Alzhei -mer′s disease and potential mechanism .Methods A rat model of AD was established through stereotactical injection ofβ-amyloid ( Aβ) into the bilateral ventricles of rats .The effects of candesartan on learning and memory were tested u-sing the Morris Water Maze .The amounts of hippocampal nNOS was detected by Western blotting .Results According to the Morris Water Maze results , the rats receiving candesartan spent substantially less time to find the platform .It im-plied that candesartan can improve the learning and memory of AD rats .Candesartan treatment also significantly reduced an increase in the level of p -nNOS.Conclusion Candesartan can improve the cognitive function of AD rats , which may be related with its capacities to reduce the level of p -nNOS mediated by Aβ.