CAJ | 학술논문

目的：观察加巴喷丁联合奥氮平对老年痴呆夜间谵妄患者睡眠障碍的治疗效果。方法抽取50例住院老年痴呆合并夜间谵妄患者，随机分为实验组（n＝25）和对照组（n＝25），实验组给予加巴喷丁联合奥氮平治疗，对照组给予奥氮平治疗，以多导睡眠生理仪评定2组患者的睡眠状况。结果实验组患者治疗后睡眠进程、睡眠结构、快动眼睡眠（REM）测量值较对照组改善更为明显，差异具有统计学意义（P＜0．05）。结论加巴喷丁联合奥氮平是一种有效治疗老年痴呆合并夜间谵妄患者睡眠障碍的方法，值得临床推广并进一步探讨其机制。
목적：관찰가파분정연합오담평대노년치태야간섬망환자수면장애적치료효과。방법추취50례주원노년치태합병야간섬망환자，수궤분위실험조（n＝25）화대조조（n＝25），실험조급여가파분정연합오담평치료，대조조급여오담평치료，이다도수면생리의평정2조환자적수면상황。결과실험조환자치료후수면진정、수면결구、쾌동안수면（REM）측량치교대조조개선경위명현，차이구유통계학의의（P＜0．05）。결론가파분정연합오담평시일충유효치료노년치태합병야간섬망환자수면장애적방법，치득림상추엄병진일보탐토기궤제。
Objective To observe the therapeutic effects of gabapentin and olanzapine combination on the sleep dis -orders of Alzheimer′s disease patients with delirium .Methods A total of 50 Alzheimer′s disease patients with delirium in our hospital were randomly divided into a treatment group ( n=25 ) and a control group ( n=25 ) .The treatment group was administrated with gabapentin and olanzapine , while the control group received olanzapine alone .Then their sleep patterns were assessed by polysomnography ( PSG) .Results Patients receiving gabapentin and olanzapine therapy pres-ented remarkably improved sleeping process , sleep structure , and REM measurements than those given olanzapine alone (P<0.05).Conclusion The combination of gabapentin and olanzapine can be applied to treat Alzheimer ′s disease pa-tients with delirium , and the mechanism involved required further discussion .