CAJ | 학술논문

目的分析组织型纤溶酶原激活剂(tPA)治疗儿童塑型性支气管炎(CB)的临床疗效.方法收集天津市儿童医院2013年9月至2015年1月住院并通过支气管镜局部使用tPA治疗的CB患儿资料,分析tPA的治疗效果及安全性,包括患儿的临床表现、影像学改变及随访情况.结果所有患儿经支气管镜介入及tPA治疗后均取出大量的塑型物质,临床表现包括呼吸、体温、经皮测血氧饱和度及影像学改变均有明显改善,安全性良好.结论支气管镜是治疗CB的有效方法,配合使用tPA能够取得更好的临床疗效,该方法安全有效,宜在疾病发生的早期应用,以防止严重的呼吸道阻塞等并发症发生.
목적 분석조직형섬용매원격활제(tPA)치료인동소형성지기관염(CB)적림상료효.방법 수집천진시인동의원2013년9월지2015년1월주원병통과지기관경국부사용tPA치료적CB환인자료,분석tPA적치료효과급안전성,포괄환인적림상표현、영상학개변급수방정황.결과 소유환인경지기관경개입급tPA치료후균취출대량적소형물질,림상표현포괄호흡、체온、경피측혈양포화도급영상학개변균유명현개선,안전성량호.결론 지기관경시치료CB적유효방법,배합사용tPA능구취득경호적림상료효,해방법안전유효,의재질병발생적조기응용,이방지엄중적호흡도조새등병발증발생.
Objective To evaluate the clinical efficacy of tissue-type plasminogen activator (tPA) treatment of children with plastic bronchitis.Methods The study retrospectively reviewed the clinical data of the children with plastic bronchitis who were admitted to Tianjin Children's Hospital from September 2013 to January 2015 and were treated with tissue-type plasminogen activator.This study analyzed the effect and safety of tPA treatment,including clinical and radiological changes and follow-ups.Results A lot of plastic secretions were safely removed from the bronchial tubes in all children and clinical manifestations including breathing,body temperature,transcutaneous oxygen saturation and image changes were significantly improved.Conclusions Bronchoscopy is an effective way to treat plastic bronchitis,but with the use of tPA a better clinical efficacy could be achieved.The method is safe and effective and should be applied early in the patients in order to prevent the occurrence of severe airway obstruction complications.