临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
10期
1867-1869
,共3页
翟娜%齐卫斌%魏江玲%张军华%曹巧娜%魏彦敏%邱静静%冯敬普
翟娜%齊衛斌%魏江玲%張軍華%曹巧娜%魏彥敏%邱靜靜%馮敬普
적나%제위빈%위강령%장군화%조교나%위언민%구정정%풍경보
咖啡因%超低出生体重儿%呼吸暂停%疗效
咖啡因%超低齣生體重兒%呼吸暫停%療效
가배인%초저출생체중인%호흡잠정%료효
caffeine%low birth weight children%apnea%efficacy
目的 探讨预防性应用咖啡因防治超低出生体重儿呼吸暂停的临床效果,以期降低新生儿并发症发生率. 方法 选取90例超低出生体重儿为研究对象,按住院号单双分成两组,对照组45例,予氨茶碱预防呼吸暂停,观察组45例,予以咖啡因预防呼吸暂停,观察治疗后在呼吸暂停发生率和相关指标变化. 结果 对照组在出生后10 d内、胎龄32周前呼吸暂停发生率分别为42. 22%、48. 89%,观察组相对应的分别为11. 11%、13. 33%,两组比较差异有统计学意义(P<0. 05);两组治疗后吸氧时间、体重增加至2 kg日龄,住院时间,机械通气发生率,硬肿症、败血症、颅内出血等并发症发生率、β-内啡肽水平比较差异均有统计学意义(P均<0. 05);在空腹血糖、钾、动脉血氧分压、动脉血二氧化碳分压、动脉血氧饱和度比较均无统计学意义(P均>0. 05). 结论 咖啡因能有效防治超低出生体重儿呼吸暂停发生率,且安全性好.
目的 探討預防性應用咖啡因防治超低齣生體重兒呼吸暫停的臨床效果,以期降低新生兒併髮癥髮生率. 方法 選取90例超低齣生體重兒為研究對象,按住院號單雙分成兩組,對照組45例,予氨茶堿預防呼吸暫停,觀察組45例,予以咖啡因預防呼吸暫停,觀察治療後在呼吸暫停髮生率和相關指標變化. 結果 對照組在齣生後10 d內、胎齡32週前呼吸暫停髮生率分彆為42. 22%、48. 89%,觀察組相對應的分彆為11. 11%、13. 33%,兩組比較差異有統計學意義(P<0. 05);兩組治療後吸氧時間、體重增加至2 kg日齡,住院時間,機械通氣髮生率,硬腫癥、敗血癥、顱內齣血等併髮癥髮生率、β-內啡肽水平比較差異均有統計學意義(P均<0. 05);在空腹血糖、鉀、動脈血氧分壓、動脈血二氧化碳分壓、動脈血氧飽和度比較均無統計學意義(P均>0. 05). 結論 咖啡因能有效防治超低齣生體重兒呼吸暫停髮生率,且安全性好.
목적 탐토예방성응용가배인방치초저출생체중인호흡잠정적림상효과,이기강저신생인병발증발생솔. 방법 선취90례초저출생체중인위연구대상,안주원호단쌍분성량조,대조조45례,여안다감예방호흡잠정,관찰조45례,여이가배인예방호흡잠정,관찰치료후재호흡잠정발생솔화상관지표변화. 결과 대조조재출생후10 d내、태령32주전호흡잠정발생솔분별위42. 22%、48. 89%,관찰조상대응적분별위11. 11%、13. 33%,량조비교차이유통계학의의(P<0. 05);량조치료후흡양시간、체중증가지2 kg일령,주원시간,궤계통기발생솔,경종증、패혈증、로내출혈등병발증발생솔、β-내배태수평비교차이균유통계학의의(P균<0. 05);재공복혈당、갑、동맥혈양분압、동맥혈이양화탄분압、동맥혈양포화도비교균무통계학의의(P균>0. 05). 결론 가배인능유효방치초저출생체중인호흡잠정발생솔,차안전성호.
Objective To investigate the prophylactic efficacy of caffeine in the prevention of apnea in low birth weight children. Methods 90 cases of low birth weight children were evenly divided into two groups according to hospital number of odd and even. The control group was given aminophylline to prevent apnea, and the observation group was given caffeine to prevent apnea. The incidence of apnea and related indicators were observed after treat-ment. Results The incidence of apnea within postnatal 10 days was 42. 22%, and 48. 89% 32-week gestational age before in the control group, which was 11. 11% and 13. 33% in the observation group, respectively ( P<0. 05 ) . There were significant differences in oxygen time after treatment, time of weight increased to 2kg, duration of hospital stay, incidence of mechanical ventilation, scleroderma, sepsis, incidence of intracranial hemorrhage and other com-plications,β-endorphin level between the two groups (P<0. 05). There was no significant difference in fasting blood glucose, potassium, blood pressure, and arterial carbon dioxide partial pressure of arterial oxygen saturation ( P>0. 05). Conclusion The application of caffeine can effectively decrease the incidence of apnea in low birth weight children.
