CAJ | 학술논문

目的观察不使用长效β2-激动剂情况下,应用噻托溴铵联合吸入糖皮质激素对哮喘-慢阻肺重叠综合征( ACOS)患者的治疗作用,并与单用噻托溴铵及单纯吸入糖皮质激素的治疗手段进行对比. 方法根据"ACOS"诊断标准选择60例患者,分为噻托溴铵联合布地奈德粉吸入剂组、单用布地奈德粉吸入剂组、单用噻托溴铵组,三组分别进行肺功能、ACT、CAT及急性加重次数的比较. 结果治疗后3组患者中噻托溴铵联合布地奈德 (C)组肺功能改善率明显高于噻托溴铵(A)组、布地奈德粉吸入剂(B)组(P<0. 05).治疗后三组患者用于哮喘症状评估的ACT评分噻托溴铵联合布地奈德 ( C)组较单用噻托溴铵、单用布地奈德治疗的两组症状改善更明显 (P<0. 05),而治疗后三组患者CAT评分噻托溴铵联合布地奈德 (C)组较单用噻托溴铵、单用布地奈德治疗的两组症状改善更明显. 结论噻托溴铵联合糖皮质激素吸人治疗可以明显改善ACOS患者的肺功能和临床症状,减少急性发作次数,其疗效优于单用糖皮质激素吸入和单用噻托溴铵吸入治疗,可改善其短期预后.
목적 관찰불사용장효β2-격동제정황하,응용새탁추안연합흡입당피질격소대효천-만조폐중첩종합정( ACOS)환자적치료작용,병여단용새탁추안급단순흡입당피질격소적치료수단진행대비. 방법근거"ACOS"진단표준선택60례환자,분위새탁추안연합포지내덕분흡입제조、단용포지내덕분흡입제조、단용새탁추안조,삼조분별진행폐공능、ACT、CAT급급성가중차수적비교. 결과 치료후3조환자중새탁추안연합포지내덕 (C)조폐공능개선솔명현고우새탁추안(A)조、포지내덕분흡입제(B)조(P<0. 05).치료후삼조환자용우효천증상평고적ACT평분새탁추안연합포지내덕 ( C)조교단용새탁추안、단용포지내덕치료적량조증상개선경명현 (P<0. 05),이치료후삼조환자CAT평분새탁추안연합포지내덕 (C)조교단용새탁추안、단용포지내덕치료적량조증상개선경명현. 결론 새탁추안연합당피질격소흡인치료가이명현개선ACOS환자적폐공능화림상증상,감소급성발작차수,기료효우우단용당피질격소흡입화단용새탁추안흡입치료,가개선기단기예후.
Objective To observe the clinical curative effect of tiotropium bromide combined with inhaled corticosteroids in the treatment of asthma-COPD overlap syndrome ( ACOS ) without using long-acting β2 agonist. Methods 60 patients which met 'ACOS' diagnostic criteria were randomly divided into the tiotropium bromide group, and the budesonide group and the combined inhalation group. Their lung function, ACT score, CAT score and num-bers of exacerbation were compared. Results After treatment, the improvement of lung function was more pro-nounced in the combined inhalation group than in the rest two groups ( P<0. 05 ) . ACT scores were superior in the combined inhalation group than in the rest two groups (P<0. 05). Conclusion Tiotropium bromide joint glucocorti-coid inhalation can significantly improve lung function and symptoms of ACOS and reduce the numbers of exacerba-tion, and its efficacy is superior to single-use inhaled corticosteroids and tiotropium bromide.