临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
10期
1850-1853
,共4页
阻塞性睡眠呼吸暂停综合征%2型糖尿病%血糖波动%炎症反应
阻塞性睡眠呼吸暫停綜閤徵%2型糖尿病%血糖波動%炎癥反應
조새성수면호흡잠정종합정%2형당뇨병%혈당파동%염증반응
obstructive sleep apnea syndrome%type2 diabetes mellitus%glucose fluctuation%inflammation
目的 探讨2型糖尿病(T2DM)并阻塞性睡眠呼吸暂停综合征(OSAS)患者血糖波动与炎症反应相关性研究. 方法 选取入住我院的32例T2DM并OSAS患者作为观察组, 32例T2DM患者作为对照组.检测两组患者血清IL-6、TNF-α、MCP水平,并利用动态血糖监测系统测量日平均血糖波动( MAGE)、血糖水平标准差( SDBG)、餐后血糖波动幅度( MPPGE). 结果 观察组MAGE、SDBG 、MPPGE水平均明显高于对照组(P<0. 05). 观察组的炎症因子IL-6、TNF-α和MCP水平明显高于对照组(P<0. 05). Spearman相关分析示IL-6、TNF-α水平与MAGE、SDBG、MPPGE 呈正相关( P <0. 05 ) , MCP 水平与 MPPGE 呈正相关( P <0. 05). 结论 T2DM 合并OSAS 患者血糖波动与体内炎症反应有一定相关性,及时有效的控制血糖波动,有可能是减轻炎症反应和缓解病情的关键.
目的 探討2型糖尿病(T2DM)併阻塞性睡眠呼吸暫停綜閤徵(OSAS)患者血糖波動與炎癥反應相關性研究. 方法 選取入住我院的32例T2DM併OSAS患者作為觀察組, 32例T2DM患者作為對照組.檢測兩組患者血清IL-6、TNF-α、MCP水平,併利用動態血糖鑑測繫統測量日平均血糖波動( MAGE)、血糖水平標準差( SDBG)、餐後血糖波動幅度( MPPGE). 結果 觀察組MAGE、SDBG 、MPPGE水平均明顯高于對照組(P<0. 05). 觀察組的炎癥因子IL-6、TNF-α和MCP水平明顯高于對照組(P<0. 05). Spearman相關分析示IL-6、TNF-α水平與MAGE、SDBG、MPPGE 呈正相關( P <0. 05 ) , MCP 水平與 MPPGE 呈正相關( P <0. 05). 結論 T2DM 閤併OSAS 患者血糖波動與體內炎癥反應有一定相關性,及時有效的控製血糖波動,有可能是減輕炎癥反應和緩解病情的關鍵.
목적 탐토2형당뇨병(T2DM)병조새성수면호흡잠정종합정(OSAS)환자혈당파동여염증반응상관성연구. 방법 선취입주아원적32례T2DM병OSAS환자작위관찰조, 32례T2DM환자작위대조조.검측량조환자혈청IL-6、TNF-α、MCP수평,병이용동태혈당감측계통측량일평균혈당파동( MAGE)、혈당수평표준차( SDBG)、찬후혈당파동폭도( MPPGE). 결과 관찰조MAGE、SDBG 、MPPGE수평균명현고우대조조(P<0. 05). 관찰조적염증인자IL-6、TNF-α화MCP수평명현고우대조조(P<0. 05). Spearman상관분석시IL-6、TNF-α수평여MAGE、SDBG、MPPGE 정정상관( P <0. 05 ) , MCP 수평여 MPPGE 정정상관( P <0. 05). 결론 T2DM 합병OSAS 환자혈당파동여체내염증반응유일정상관성,급시유효적공제혈당파동,유가능시감경염증반응화완해병정적관건.
Objective To evaluate the association between glucose fluctuation and inflammation in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnea syndrome (OSAS). Methods 32 T2DM patients complicated with OSAS were enrolled in this study as observation group, and another 32 patients only with T2DM were selected as the control group. The levels of serum IL-6, TNF-αand MCP in the two groups were measured and recorded. The dynamic blood glucose monitoring system was used to measure MAGE, SDBG and MPPGE. Results Compared with the control group, the observation group had higher levels of MAGE, SDBG, MPPGE, IL-6, TNF-αand MCP. Sperman relation analysis proved that the contents of IL-6 and TNF-α were positively associated with the levels of MAGE, SDBG and MPPGE (P<0. 05). The level of MCP was positively related with MPPGE (P<0. 05). Conclusion Glucose fluctuation has a certain correlation with inflammation in T2DM patients complicated with OS-AS. Therefore, the effective and timely control of glucose fluctuation can alleviate inflammation injury.
