临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
10期
1808-1811
,共4页
枸橼酸西地那非%妊娠%肺动脉高压%血流动力学%血气分析
枸櫞痠西地那非%妊娠%肺動脈高壓%血流動力學%血氣分析
구연산서지나비%임신%폐동맥고압%혈류동역학%혈기분석
sildenafil citrate%pregnancy%pulmonary hypertension%hemodynamics%blood gas analysis
目的 探讨枸橼酸西地那治疗妊娠合并肺动脉高压患者的临床疗效. 方法 将我院97例妊娠合并PAH的患者随机分为观察组47例及对照组50例,两组患者均给予常规治疗,观察组患者同时给予枸橼酸西地那非,观察两组患者的妊娠结局及各项指标变化情况,以及心功能及PAH转归情况. 结果 治疗后观察组患者的妊娠结局显著优于对照组,同时左室射血分数、氧分压、血氧饱和度显著优于对照组患者,差异均具有统计学意义(P<0. 05);并且对照组患者经过治疗PAH程度及心功能进展的例数显著高于观察组患者,差异具有统计学意义(P<0. 05). 结论 枸橼酸西地那非治疗妊娠合并肺动脉高压效果理想,能够改善患者的各项指标及妊娠结局,阻止心功能及PAH的进一步加重.
目的 探討枸櫞痠西地那治療妊娠閤併肺動脈高壓患者的臨床療效. 方法 將我院97例妊娠閤併PAH的患者隨機分為觀察組47例及對照組50例,兩組患者均給予常規治療,觀察組患者同時給予枸櫞痠西地那非,觀察兩組患者的妊娠結跼及各項指標變化情況,以及心功能及PAH轉歸情況. 結果 治療後觀察組患者的妊娠結跼顯著優于對照組,同時左室射血分數、氧分壓、血氧飽和度顯著優于對照組患者,差異均具有統計學意義(P<0. 05);併且對照組患者經過治療PAH程度及心功能進展的例數顯著高于觀察組患者,差異具有統計學意義(P<0. 05). 結論 枸櫞痠西地那非治療妊娠閤併肺動脈高壓效果理想,能夠改善患者的各項指標及妊娠結跼,阻止心功能及PAH的進一步加重.
목적 탐토구연산서지나치료임신합병폐동맥고압환자적림상료효. 방법 장아원97례임신합병PAH적환자수궤분위관찰조47례급대조조50례,량조환자균급여상규치료,관찰조환자동시급여구연산서지나비,관찰량조환자적임신결국급각항지표변화정황,이급심공능급PAH전귀정황. 결과 치료후관찰조환자적임신결국현저우우대조조,동시좌실사혈분수、양분압、혈양포화도현저우우대조조환자,차이균구유통계학의의(P<0. 05);병차대조조환자경과치료PAH정도급심공능진전적례수현저고우관찰조환자,차이구유통계학의의(P<0. 05). 결론 구연산서지나비치료임신합병폐동맥고압효과이상,능구개선환자적각항지표급임신결국,조지심공능급PAH적진일보가중.
Objective To investigate the clinical efficacy of sildenafil citrate in the treatment of pulmonary hypertension during pregnancy. Methods 97 pregnant patients complicated with PAH in our hospital were randomly divided into the observation group (47 cases) and the control group (50 cases). All patients were given conventional treatment, and the observation group was additionally treated with sildenafil citrate. The changes of pregnancy out-come, blood gas analysis and blood dynamics, blood coagulation and biochemical indexes were observed and com-pared between the two groups before and after the treatment, and their cardiac function and PAH outcome were also recorded. Results After the treatment, their pregnancy outcome, left ventricular ejection fraction, oxygen partial pressure and saturation of blood oxygen were obviously better in the observation group than in the control group ( P<0. 05 ) . The progress in PAH level and heart function was more pronounced in the observation group than in the con-trol group (P<0. 05). Conclusion Sildenafil citrate therapy has satisfying curative effect in the treatment of pul-monary hypertension during pregnancy, which can improve hemodynamic and blood gas indexes and prevent heart function and PAH aggravation.
