CAJ | 학술논문

目的回顾性分析肺结核患者( PTB)与人类免疫缺陷病毒( HIV)感染/艾滋病( AIDS)合并PTB患者的分枝杆菌药敏和菌株鉴定结果,期望为HIV感染/AIDS合并PTB患者早期有效抗结核治疗提供数据参考.方法搜集重庆市公共卫生医疗救治中心结核科和感染科2013年1月1日至2013年12月31日期间1708例无HIV感染PTB患者和106例HIV感染/AIDS合并PTB患者临床资料,统计分枝杆菌药敏试验和菌株鉴定的结果,分析耐药特征,采用卡方检验,以P<0. 05为差异具有统计学意义. 结果无HIV感染PTB组与HIV感染/AIDS合并PTB组的总耐药率、初治耐药率、复治耐药率差异均有显著统计学意义( P均<0. 01);HIV感染合并PTB组耐药率12. 5%(2/16)与AIDS合并PTB组耐药率24. 4%(22/90)差异无显著统计学意义(P>0. 05).结论该中心收治的痰结核培养阳性患者中,HIV感染/AIDS合并PTB患者耐药趋势远低于PTB患者,HIV感染合并PTB组耐药状况与AIDS合并PTB组大体一致.
목적 회고성분석폐결핵환자( PTB)여인류면역결함병독( HIV)감염/애자병( AIDS)합병PTB환자적분지간균약민화균주감정결과,기망위HIV감염/AIDS합병PTB환자조기유효항결핵치료제공수거삼고.방법 수집중경시공공위생의료구치중심결핵과화감염과2013년1월1일지2013년12월31일기간1708례무HIV감염PTB환자화106례HIV감염/AIDS합병PTB환자림상자료,통계분지간균약민시험화균주감정적결과,분석내약특정,채용잡방검험,이P<0. 05위차이구유통계학의의. 결과 무HIV감염PTB조여HIV감염/AIDS합병PTB조적총내약솔、초치내약솔、복치내약솔차이균유현저통계학의의( P균<0. 01);HIV감염합병PTB조내약솔12. 5%(2/16)여AIDS합병PTB조내약솔24. 4%(22/90)차이무현저통계학의의(P>0. 05).결론 해중심수치적담결핵배양양성환자중,HIV감염/AIDS합병PTB환자내약추세원저우PTB환자,HIV감염합병PTB조내약상황여AIDS합병PTB조대체일치.
Objective To comparatively analyze the results of mycobacteria susceptibility test between pul-monary tuberculosis patients and pulmonary tuberculosis patients complicated with HIV/AIDS, in order to provide a reference for early intervention of pulmonary tuberculosis patients with HIV/AIDS. Methods The clinical data were collected from tuberculosis department and infectious disease department of public health medical center in Chongqing from Jan. 1, 2013 to Dec. 31, 2013, involving 1708 cases of pulmonary tuberculosis patients and 108 cases of pul-monary tuberculosis patients complicated with HIV/AIDS. Chi-square test was used to analyze resistance characteris-tics, and while P-values<0. 05, the difference between the two means was considered statistically significant. Re-sults The total resistance rate, initial drug-resistance rate, re-treatment drug-resistance rate was obviously higher in pulmonary tuberculosis patients than in pulmonary tuberculosis patients complicated with HIV/AIDS respectively ( all P<0. 01). There was no significant difference in total drug-resistance rate between pulmonary tuberculosis patients with HIV and pulmonary tuberculosis patients with AIDS [12. 5% (2/16), 24. 4% (22/90), χ2 =16. 67, P <0. 01 ] . Conclusion The pulmonary tuberculosis patients complicated with HIV/AIDS show a certain lower drug-re-sistant trend than pulmonary tuberculosis patients with positive sputum culture. Drug-resistance status is generally similar between pulmonary tuberculosis patients with HIV and pulmonary tuberculosis patients with AIDS.