临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
10期
1753-1755
,共3页
分枝杆菌%药敏试验%一线抗结核药%耐多药结核
分枝桿菌%藥敏試驗%一線抗結覈藥%耐多藥結覈
분지간균%약민시험%일선항결핵약%내다약결핵
mycobacteria%drug susceptibility test%first line drugs for tuberculosis%multi-drug resistant tu-berculosis
目的 了解我院近两年就诊患者分枝杆菌对10种药物的耐药状况,为临床化疗方案的选择提供科学依据. 方法 将收集到的痰标本进行分离培养,然后利用噻吩-2-羧酸肼( TCH)培养基生长试验、硝酸还原试验以及烟酸试验对其进行菌种鉴定,并同时采用绝对浓度法对10种抗结核药物进行药敏试验. 结果结核分枝杆菌(包括人型和牛型)共377株,对4种一线抗结核药的总耐药率为15. 11%( 57/377 ) ,耐多药结核(MDR-TB)有3株(0. 8%). 非结核分枝杆菌128 株,对4 种一线抗结核药的总耐药率为66. 9%(97/128),对10种药物全耐药的有22株(17. 1%). 结论 分枝杆菌(尤其是非结核分枝杆菌)对常用抗结核药物的耐药率高,应加强抗结核药物的耐药性监测,并根据药敏结果选择科学有效的化疗方案.
目的 瞭解我院近兩年就診患者分枝桿菌對10種藥物的耐藥狀況,為臨床化療方案的選擇提供科學依據. 方法 將收集到的痰標本進行分離培養,然後利用噻吩-2-羧痠肼( TCH)培養基生長試驗、硝痠還原試驗以及煙痠試驗對其進行菌種鑒定,併同時採用絕對濃度法對10種抗結覈藥物進行藥敏試驗. 結果結覈分枝桿菌(包括人型和牛型)共377株,對4種一線抗結覈藥的總耐藥率為15. 11%( 57/377 ) ,耐多藥結覈(MDR-TB)有3株(0. 8%). 非結覈分枝桿菌128 株,對4 種一線抗結覈藥的總耐藥率為66. 9%(97/128),對10種藥物全耐藥的有22株(17. 1%). 結論 分枝桿菌(尤其是非結覈分枝桿菌)對常用抗結覈藥物的耐藥率高,應加彊抗結覈藥物的耐藥性鑑測,併根據藥敏結果選擇科學有效的化療方案.
목적 료해아원근량년취진환자분지간균대10충약물적내약상황,위림상화료방안적선택제공과학의거. 방법 장수집도적담표본진행분리배양,연후이용새분-2-최산정( TCH)배양기생장시험、초산환원시험이급연산시험대기진행균충감정,병동시채용절대농도법대10충항결핵약물진행약민시험. 결과결핵분지간균(포괄인형화우형)공377주,대4충일선항결핵약적총내약솔위15. 11%( 57/377 ) ,내다약결핵(MDR-TB)유3주(0. 8%). 비결핵분지간균128 주,대4 충일선항결핵약적총내약솔위66. 9%(97/128),대10충약물전내약적유22주(17. 1%). 결론 분지간균(우기시비결핵분지간균)대상용항결핵약물적내약솔고,응가강항결핵약물적내약성감측,병근거약민결과선택과학유효적화료방안.
Objective To understand the drug resistance of mycobacteria to 10 drugs in our hospital in re-cent two years, in order to provide scientific basis for clinical choice of chemotherapy. Methods Bacteria were iso-lated and cultured from the sputum samples, then they were identified by PNB and TCH, and at the same time they were tested with absolute concentration method for 10 kinds of anti-tuberculosis drugs. Results There were 377 strains of tuberculosis mycobacteria, including human type and bovine type, which showed 15. 11% resistance to 4 kinds of first-line drugs ( 57/377 ) , and 3 strains of them were multi-drug resistant ( MDR-TB ) ( 0. 8%) . There were 128 strains of non-tuberculosis mycobacteria, and the total resistance rate for 4 first-line drugs was 66. 9% (97/128), including 22 strains resistant to all 10 types of drugs. Conclusion Mycobacteria, especially non-tuberculosis mycobacteria, show a high resistance to many drugs, so the monitoring of drug resistance to anti-tuberculosis drugs should be strengthened, and the reasonable and efficient chemotherapy plans should be chosen according to the drug sensitive test results.
