临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
10期
1791-1793
,共3页
人肺%腺癌%B7-H4%免疫组化
人肺%腺癌%B7-H4%免疫組化
인폐%선암%B7-H4%면역조화
human lung%adenocarcinoma%B7-H4%immune histochemistry
目的 研究共信号分子B7-H4在人肺腺癌组织中的表达及临床意义. 方法 收集2013年10月-2014年10月手术切除的肺腺癌患者肺癌组织标本94份,正常肺组织标本20份,应用免疫组织化学法,分别检测组织标本中B7-H4的表达水平. 结果 B7-H4在20份正常人肺组织中表达较低,在94份人肺腺癌组织中的阳性表达率为67. 32%,在合并有淋巴结转移的肺腺癌组织中B7-H4的阳性表达率为73. 24%. 低分化组肺腺癌组织B7-H4阳性表达率(84. 82%)明显高于中分化组(77. 38%)和高分化组(62. 51%). 结论共信号分子B7-H4在肺腺癌组织中表达上调,有可能成为评价肺腺癌分化程度和淋巴结转移的指标之一.
目的 研究共信號分子B7-H4在人肺腺癌組織中的錶達及臨床意義. 方法 收集2013年10月-2014年10月手術切除的肺腺癌患者肺癌組織標本94份,正常肺組織標本20份,應用免疫組織化學法,分彆檢測組織標本中B7-H4的錶達水平. 結果 B7-H4在20份正常人肺組織中錶達較低,在94份人肺腺癌組織中的暘性錶達率為67. 32%,在閤併有淋巴結轉移的肺腺癌組織中B7-H4的暘性錶達率為73. 24%. 低分化組肺腺癌組織B7-H4暘性錶達率(84. 82%)明顯高于中分化組(77. 38%)和高分化組(62. 51%). 結論共信號分子B7-H4在肺腺癌組織中錶達上調,有可能成為評價肺腺癌分化程度和淋巴結轉移的指標之一.
목적 연구공신호분자B7-H4재인폐선암조직중적표체급림상의의. 방법 수집2013년10월-2014년10월수술절제적폐선암환자폐암조직표본94빈,정상폐조직표본20빈,응용면역조직화학법,분별검측조직표본중B7-H4적표체수평. 결과 B7-H4재20빈정상인폐조직중표체교저,재94빈인폐선암조직중적양성표체솔위67. 32%,재합병유림파결전이적폐선암조직중B7-H4적양성표체솔위73. 24%. 저분화조폐선암조직B7-H4양성표체솔(84. 82%)명현고우중분화조(77. 38%)화고분화조(62. 51%). 결론공신호분자B7-H4재폐선암조직중표체상조,유가능성위평개폐선암분화정도화림파결전이적지표지일.
Objective To study the expression and its clinical significance of signal molecule B7-H4 in hu-man pulmonary adenocarcinoma tissues. Methods 94 tissue samples of human pulmonary adenocarcinoma and 20 normal lung tissues were collected during Oct. 2013 to Oct. 2014. The expression of B7-H4 in lung tissues was identi-fied by immune histochemistry. Results The expression of B7-H4 was lower in 20 normal lung tissue, while its posi-tive expression rate was 67. 32% in 94 tissue samples of pulmonary adenocarcinoma, and 73. 24% in samples com-bined with metastasis of lymph nodes. The positive expression rate of B7-H4 was higher in poorly differentiated group (84. 82%) than that in the middle (77. 38%) and high differentiation group (62. 51%). Conclusion The expres-sion of B7-H4 is up-regulated in tissues of pulmonary adnocarcinoma, and it might be one of the potential biomarkers for the evaluation of stage differentiation and metastasis of human pulmonary adenocarcinoma.
