现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
19期
2781-2783
,共3页
徐倩%王秀秀%高珊%姚民秀
徐倩%王秀秀%高珊%姚民秀
서천%왕수수%고산%요민수
IGF-1%IGFBP-3%2型糖尿病%胃癌
IGF-1%IGFBP-3%2型糖尿病%胃癌
IGF-1%IGFBP-3%2형당뇨병%위암
IGF - 1%IGFBP - 3%type 2 diabetes mellitus%gastric cancer
目的:研究2型糖尿病(diabetes mellitus,DM)合并胃癌(gastric cancer,GC)患者血清胰岛素样生长因子-1(insulin - like growth factor -1,IGF -1)、胰岛素样生长因子结合蛋白-3(insulin - like growth factor binding protein -3,IGFBP -3)的变化。方法:选择2型 DM 患者30例(DM 组)、2型 DM 合并 GC 患者48例(DM 并 GC 组)为研究对象,ELISA 法测定血清 IGF -1、IGFBP -3水平;同时测定空腹血糖、空腹胰岛素、血脂水平。结果:DM 并 GC 组的 IGF -1、IGF -1/ IGFBP -3比值高于 DM 组(P <0.05),IGFBP -3在两组之间无统计学差异(P >0.05)。IGF -1、IGF -1/ IGFBP -3比值与空腹胰岛素水平呈正相关(r =0.598,0.626, P =0.000),IGF -1/ IGFBP -3比值是 DM 并 GC 患者淋巴结转移的危险因素(OR =2.142,P =0.001)。结论:IGF -1可能参与2型 DM 合并 GC 的发生及淋巴结转移。
目的:研究2型糖尿病(diabetes mellitus,DM)閤併胃癌(gastric cancer,GC)患者血清胰島素樣生長因子-1(insulin - like growth factor -1,IGF -1)、胰島素樣生長因子結閤蛋白-3(insulin - like growth factor binding protein -3,IGFBP -3)的變化。方法:選擇2型 DM 患者30例(DM 組)、2型 DM 閤併 GC 患者48例(DM 併 GC 組)為研究對象,ELISA 法測定血清 IGF -1、IGFBP -3水平;同時測定空腹血糖、空腹胰島素、血脂水平。結果:DM 併 GC 組的 IGF -1、IGF -1/ IGFBP -3比值高于 DM 組(P <0.05),IGFBP -3在兩組之間無統計學差異(P >0.05)。IGF -1、IGF -1/ IGFBP -3比值與空腹胰島素水平呈正相關(r =0.598,0.626, P =0.000),IGF -1/ IGFBP -3比值是 DM 併 GC 患者淋巴結轉移的危險因素(OR =2.142,P =0.001)。結論:IGF -1可能參與2型 DM 閤併 GC 的髮生及淋巴結轉移。
목적:연구2형당뇨병(diabetes mellitus,DM)합병위암(gastric cancer,GC)환자혈청이도소양생장인자-1(insulin - like growth factor -1,IGF -1)、이도소양생장인자결합단백-3(insulin - like growth factor binding protein -3,IGFBP -3)적변화。방법:선택2형 DM 환자30례(DM 조)、2형 DM 합병 GC 환자48례(DM 병 GC 조)위연구대상,ELISA 법측정혈청 IGF -1、IGFBP -3수평;동시측정공복혈당、공복이도소、혈지수평。결과:DM 병 GC 조적 IGF -1、IGF -1/ IGFBP -3비치고우 DM 조(P <0.05),IGFBP -3재량조지간무통계학차이(P >0.05)。IGF -1、IGF -1/ IGFBP -3비치여공복이도소수평정정상관(r =0.598,0.626, P =0.000),IGF -1/ IGFBP -3비치시 DM 병 GC 환자림파결전이적위험인소(OR =2.142,P =0.001)。결론:IGF -1가능삼여2형 DM 합병 GC 적발생급림파결전이。
Objective:To investigate changes of serum insulin - like growth factor - 1(IGF - 1)and insulin - like growth factor binding protein - 3( IGFBP - 3 )in patients with type 2 diabetes mellitus(DM)with gastric cancer (GC). Methods:Serum samples were collected from 30 DM patients(DM group),48 type 2 DM with GC patients (DM with GC group). ELISA was used to detect the levels of serum IGF - 1 and IGFBP - 3. Fasting plasma glucose, fasting insulin and lipids levels were measured. Results:There were higher levels of serum IGF - 1 and IGF - 1 / IG-FBP - 3 ratio in the DM with GC group than those in the DM group. There was no significant difference of serum IG-FBP - 3 in the two groups(P > 0. 05). IGF - 1 and IGF - 1 / IGFBP - 3 were positively correlated with fasting insulin (r = 0. 598,0. 626,P = 0. 000). IGF - 1 / IGFBP - 3 ratio was a risk factor of lymph node metastasis of DM with GC (OR = 2. 142,P = 0. 001). Conclusion:IGF - 1 may be involved in the development of DM with GC and lymph node metastasis.