现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
19期
2774-2777
,共4页
血管内皮生长因子%血管生成素-2%非小细胞肺癌%血管生成%预后
血管內皮生長因子%血管生成素-2%非小細胞肺癌%血管生成%預後
혈관내피생장인자%혈관생성소-2%비소세포폐암%혈관생성%예후
VEGF%Ang - 2%NSCLC%angiogenesis%prognosis
目的：检测非小细胞肺癌（NSCLC）患者血清中血管内皮生长因子（VEGF）和血管生成素-2（Ang -2）的含量，探讨血清中 VEGF 和 Ang -2与肿瘤血管生成的关系及其临床意义。方法：收集40例 NSCLC 患者血清和肿瘤组织，以40例健康志愿者血清为对照，采用 ELISA 方法检测血清中 VEGF 和 Ang -2的含量，应用免疫组化法检测肿瘤组织中的微血管密度（MVD），分析血清中 VEGF 和 Ang -2与肿瘤血管生成、临床病理资料和预后的相关性。结果：NSCLC 患者血清中 VEGF[（625.6±312.5）pg/ml]和 Ang -2[（2450.2±1021.1） pg/ ml]的含量明显高于正常对照组血清中 VEGF[（321.4±102.6）pg/ ml]和 Ang -2[（1020.6±421.6）pg/ml]的含量（P ＜0.05）。NSCLC 患者血清中 VEGF 和 Ang -2的含量均与肿瘤的 MVD 呈正相关（r =0.525，P
目的：檢測非小細胞肺癌（NSCLC）患者血清中血管內皮生長因子（VEGF）和血管生成素-2（Ang -2）的含量，探討血清中 VEGF 和 Ang -2與腫瘤血管生成的關繫及其臨床意義。方法：收集40例 NSCLC 患者血清和腫瘤組織，以40例健康誌願者血清為對照，採用 ELISA 方法檢測血清中 VEGF 和 Ang -2的含量，應用免疫組化法檢測腫瘤組織中的微血管密度（MVD），分析血清中 VEGF 和 Ang -2與腫瘤血管生成、臨床病理資料和預後的相關性。結果：NSCLC 患者血清中 VEGF[（625.6±312.5）pg/ml]和 Ang -2[（2450.2±1021.1） pg/ ml]的含量明顯高于正常對照組血清中 VEGF[（321.4±102.6）pg/ ml]和 Ang -2[（1020.6±421.6）pg/ml]的含量（P ＜0.05）。NSCLC 患者血清中 VEGF 和 Ang -2的含量均與腫瘤的 MVD 呈正相關（r =0.525，P
목적：검측비소세포폐암（NSCLC）환자혈청중혈관내피생장인자（VEGF）화혈관생성소-2（Ang -2）적함량，탐토혈청중 VEGF 화 Ang -2여종류혈관생성적관계급기림상의의。방법：수집40례 NSCLC 환자혈청화종류조직，이40례건강지원자혈청위대조，채용 ELISA 방법검측혈청중 VEGF 화 Ang -2적함량，응용면역조화법검측종류조직중적미혈관밀도（MVD），분석혈청중 VEGF 화 Ang -2여종류혈관생성、림상병리자료화예후적상관성。결과：NSCLC 환자혈청중 VEGF[（625.6±312.5）pg/ml]화 Ang -2[（2450.2±1021.1） pg/ ml]적함량명현고우정상대조조혈청중 VEGF[（321.4±102.6）pg/ ml]화 Ang -2[（1020.6±421.6）pg/ml]적함량（P ＜0.05）。NSCLC 환자혈청중 VEGF 화 Ang -2적함량균여종류적 MVD 정정상관（r =0.525，P
Objective:To investigate the expressions of VEGF and Ang - 2 in serum of patients with NSCLC,and determine their relationship with angiogenesis,the pathological characteristics and prognosis. Methods:The expression levels of VEGF and Ang - 2 in serum of patients with NSCLC were detected by using ELISA. The expression of mi-crovessel density(MVD)in tissues was determined by the immunohistochemistry. The correlations among the levels of VEGF,Ang - 2 and MVD,and their relations with the pathological features and prognosis were analyzed. Results:The serum levels of VEGF and Ang - 2 were higher in patients with NSCLC than those of controls(P < 0. 05). The levels of VEGF and Ang - 2 in serum had a positive relationship with MVD in NSCLC. The serum levels of VEGF and Ang- 2 were positively correlated with tumor size,lung metastasis,and stages of NSCLC(P < 0. 05). Overall survival in low serum levels of VEGF or Ang - 2 was longer than those in high serum levels in NSCLC(P < 0. 05). Conclusion:Both VEGF and Ang - 2 play important roles in the angiogenesis and progression of NSCLC,and they may be useful biomarkers for diagnosis and prognosis of NSCLC.
