CAJ | 학술논문

目的：探讨非小细胞肺癌（NSCLC）中 EphA2、E -钙黏蛋白（E - cadherin）的表达及意义。方法：采用免疫组织化学 SP 法，检测60例 NSCLC 及10例正常肺组织（对照组）中 EphA2、E - cadherin 的表达。结果：EphA2在 NSCLC 中的阳性表达率为80.00％，明显高于癌旁正常肺组织20.00％（P =0.001）。E - cadherin在 NSCLC 中的阳性表达率为58.33％，明显低于癌旁正常肺组织100.00％（P =0.000）。EphA2、E - cadherin蛋白在 NSCLC 中的表达差异与患者性别、年龄、病变部位无关（均 P ＞0.05），但与 NSCLC 的分化程度、临床分期、有无淋巴结转移相关（P ＜0.05）。结论：EphA2可促进肿瘤细胞的转化、增殖、迁移，E - cadherin 可促进肿瘤细胞的迁移，两者在 NSCLC 中的共同作用导致了 NSCLC 的恶性进展，可作为临床评估肺癌恶性程度的指标。
목적：탐토비소세포폐암（NSCLC）중 EphA2、E -개점단백（E - cadherin）적표체급의의。방법：채용면역조직화학 SP 법，검측60례 NSCLC 급10례정상폐조직（대조조）중 EphA2、E - cadherin 적표체。결과：EphA2재 NSCLC 중적양성표체솔위80.00％，명현고우암방정상폐조직20.00％（P =0.001）。E - cadherin재 NSCLC 중적양성표체솔위58.33％，명현저우암방정상폐조직100.00％（P =0.000）。EphA2、E - cadherin단백재 NSCLC 중적표체차이여환자성별、년령、병변부위무관（균 P ＞0.05），단여 NSCLC 적분화정도、림상분기、유무림파결전이상관（P ＜0.05）。결론：EphA2가촉진종류세포적전화、증식、천이，E - cadherin 가촉진종류세포적천이，량자재 NSCLC 중적공동작용도치료 NSCLC 적악성진전，가작위림상평고폐암악성정도적지표。
Objective:To explore the expressions and significance of EphA2 and E - cadherin in NSCLC. Meth-ods:SP immunohistochemical staining was used to examine the expressions of EphA2 and E - cadherin in 60 NSCLC specimens and in 10 normal lung tissues. Results:The positive rate of EphA2 in lung cancer was 80. 00% ,significant-ly higher than those in the normal tissues( P = 0 . 001 ). The positive rate of E - cadherin in lung cancer was 58. 33% ,significantly lower than those in the normal tissues(P = 0. 000). EphA2 and E - cadherin expressions were not correlated with age,gender and tumor position( P > 0. 05),but correlated with differential,clinical stage and lymph nodes metastasis(P < 0. 05). Conclusion:EphA2 could promotes the transformation,proliferation,migration of tumor cells. E - cadherin could promote the migration of tumor cells. All of them could lead the malignant progress of NSCLC,and could be used as a clinical evaluation index of lung cancer.