临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
10期
1770-1773
,共4页
尹凤鸣%周友乾%任彬%张海叶
尹鳳鳴%週友乾%任彬%張海葉
윤봉명%주우건%임빈%장해협
肺结核%降钙素原%可溶性髓系细胞触发受体-1
肺結覈%降鈣素原%可溶性髓繫細胞觸髮受體-1
폐결핵%강개소원%가용성수계세포촉발수체-1
MDR-TB%PCT%sTREM-1
目的 探讨血清降钙素原与sTREM-1水平对多重耐药肺结核患有者早期临床疗效的相关性研究. 方法 连续性收录自2012年4月至2014 年4 月于我院就诊并被确诊为耐多药肺结核的患者160 例.另纳入同期来院体检的志愿者60例. 采用免疫荧光法检测血清PCT,酶联免疫吸附试验( ELISA)检测血清sTREM-1. 并分析两种血清指标与耐多药肺结核的临床疗效与预后的相关性. 结果 在治疗前,肺结核患者血清PCT和sTREM-1水平明显高于对照组(0. 19 ± 0. 08 ng/ml vs 0. 03 ± 0. 01 ng /ml,181. 32 ± 34. 2 ng/mL vs 23. 5 ± 11. 6 ng/mL)(P<0. 05). 而有效组患者治疗前PCT和sTREM-1水平与无效组患者比较未见明显差异(P>0. 05),经治疗后可见有效组患者在治疗后2个月和6个月两个时间点中血清PCT和sTREM-1水平明显低于无效组患者( P<0. 05 ). 治疗后2 个月时的血清 PCT 和 sTREM-1 水平具有较高的预后评价意义(AUC分别为0. 82和0. 86). 多因素COX分析可见白蛋白,PCT以及sTREM-1水平三者是独立的危险因素(P<0. 05). 结论 血清PCT和sTREM-1的水平与耐多药肺结核患者病情程度以及临床预后密切相关.
目的 探討血清降鈣素原與sTREM-1水平對多重耐藥肺結覈患有者早期臨床療效的相關性研究. 方法 連續性收錄自2012年4月至2014 年4 月于我院就診併被確診為耐多藥肺結覈的患者160 例.另納入同期來院體檢的誌願者60例. 採用免疫熒光法檢測血清PCT,酶聯免疫吸附試驗( ELISA)檢測血清sTREM-1. 併分析兩種血清指標與耐多藥肺結覈的臨床療效與預後的相關性. 結果 在治療前,肺結覈患者血清PCT和sTREM-1水平明顯高于對照組(0. 19 ± 0. 08 ng/ml vs 0. 03 ± 0. 01 ng /ml,181. 32 ± 34. 2 ng/mL vs 23. 5 ± 11. 6 ng/mL)(P<0. 05). 而有效組患者治療前PCT和sTREM-1水平與無效組患者比較未見明顯差異(P>0. 05),經治療後可見有效組患者在治療後2箇月和6箇月兩箇時間點中血清PCT和sTREM-1水平明顯低于無效組患者( P<0. 05 ). 治療後2 箇月時的血清 PCT 和 sTREM-1 水平具有較高的預後評價意義(AUC分彆為0. 82和0. 86). 多因素COX分析可見白蛋白,PCT以及sTREM-1水平三者是獨立的危險因素(P<0. 05). 結論 血清PCT和sTREM-1的水平與耐多藥肺結覈患者病情程度以及臨床預後密切相關.
목적 탐토혈청강개소원여sTREM-1수평대다중내약폐결핵환유자조기림상료효적상관성연구. 방법 련속성수록자2012년4월지2014 년4 월우아원취진병피학진위내다약폐결핵적환자160 례.령납입동기래원체검적지원자60례. 채용면역형광법검측혈청PCT,매련면역흡부시험( ELISA)검측혈청sTREM-1. 병분석량충혈청지표여내다약폐결핵적림상료효여예후적상관성. 결과 재치료전,폐결핵환자혈청PCT화sTREM-1수평명현고우대조조(0. 19 ± 0. 08 ng/ml vs 0. 03 ± 0. 01 ng /ml,181. 32 ± 34. 2 ng/mL vs 23. 5 ± 11. 6 ng/mL)(P<0. 05). 이유효조환자치료전PCT화sTREM-1수평여무효조환자비교미견명현차이(P>0. 05),경치료후가견유효조환자재치료후2개월화6개월량개시간점중혈청PCT화sTREM-1수평명현저우무효조환자( P<0. 05 ). 치료후2 개월시적혈청 PCT 화 sTREM-1 수평구유교고적예후평개의의(AUC분별위0. 82화0. 86). 다인소COX분석가견백단백,PCT이급sTREM-1수평삼자시독립적위험인소(P<0. 05). 결론 혈청PCT화sTREM-1적수평여내다약폐결핵환자병정정도이급림상예후밀절상관.
Objective To investigate the the correlation of serum PCT and sTREM-1 with clinical prognosis in patients with multi-drug resistant tuberculosis. Methods 160 patients with multi-drug resistant tuberculosis ( MDR-TB) were enrolled in this study and were divided into two groups: the effective group and the ineffective group. 60 healthy people were taken as the control group. Serum concentration of PCT and sTREM-1 were detected by electrochemiluminescence immunoassay method and enzyme-linked immunosorbent assay, respectively. Results The concentration of PCT and sTREM-1in MDR-TB patients were significantly higher than those of healthy controls (0. 19 ± 0. 08 ng/ml vs 0. 03 ± 0. 01 ng /ml, 181. 32 ± 34. 2 ng/mL vs 23. 5 ± 11. 6 ng/mL) (P<0. 05). There was no significant difference in the levels of PCT and sTREM-1 between the effective group and the ineffective group be-fore treatment (P>0. 05). The levels of PCT and sTREM-1 in the effective group were significantly lower than those in the ineffective group 2 and 6 months after the treatment (P<0. 05). ROC analysis showed that the levels of PCT and STREM-1 2 months after the treatment had the highest diagnostic value as AUC was 0. 82 and 0. 86 respectively. Multi-factor COX regression analysis showed that albumin, PCT and sTREM-1 were independent risk factors in MDR-TB patients ( P<0. 05 ) . Conclusion The serum contents of PCT and sTREM-1 are significantly related with the progression of disease in patients with MDR-TB.
