CAJ | 학술논문

目的：提高医用低模量近β型TLM(Ti-25Nb-3Zr-2Sn-3Mo)钛合金的抗菌性能。方法在200℃条件下,在硝酸银溶液中对TLM合金分别进行12,24 h水热处理,在其表面制备含银TiO2抗菌薄膜。通过SEM,XRD,XPS等表征薄膜的微观结构及状态。以去离子水水热处理TLM合金作为参照,比较薄膜的亲水性,并采用抑菌圈法研究其抗菌性能。结果 SEM,XRD及XPS分析表明,水热处理后,TLM合金表面形成了TiO2纳米晶粒组成的薄膜,薄膜中的钛和铌分别以TiO2和Nb2 O5形式存在,银以金属态存在。接触角测试结果表明,水热处理试样表面具有良好的光致亲水性,紫外光照射30 min后,水接触角从108。降低到10。以下。抗菌实验中,水热处理试样在对大肠杆菌和金黄葡萄球菌培养24 h后,产生了明显的抑菌圈,相比之下,对金黄葡萄球菌的抑菌圈较宽。结论硝酸银溶液水热法在医用钛合金表面可以合成含银TiO2薄膜,具有工艺简便、处理温度低、抗菌效果明显等优点。
목적：제고의용저모량근β형TLM(Ti-25Nb-3Zr-2Sn-3Mo)태합금적항균성능。방법재200℃조건하,재초산은용액중대TLM합금분별진행12,24 h수열처리,재기표면제비함은TiO2항균박막。통과SEM,XRD,XPS등표정박막적미관결구급상태。이거리자수수열처리TLM합금작위삼조,비교박막적친수성,병채용억균권법연구기항균성능。결과 SEM,XRD급XPS분석표명,수열처리후,TLM합금표면형성료TiO2납미정립조성적박막,박막중적태화니분별이TiO2화Nb2 O5형식존재,은이금속태존재。접촉각측시결과표명,수열처리시양표면구유량호적광치친수성,자외광조사30 min후,수접촉각종108。강저도10。이하。항균실험중,수열처리시양재대대장간균화금황포도구균배양24 h후,산생료명현적억균권,상비지하,대금황포도구균적억균권교관。결론초산은용액수열법재의용태합금표면가이합성함은TiO2박막,구유공예간편、처리온도저、항균효과명현등우점。
Objective To improve the antimicrobial properties of nearβ-type biomedical titanium alloy TLM (Ti-25Nb-3Zr-2Sn-3Mo) with low modulus. Methods TLM alloy was hydrothermally treated in silver nitrate solution at 200℃ with AgNO3 solution for 12 h and 24 h respectively to prepare antibacterial Ag-containing TiO2 film on its surface. The microstructure and status of the film were characterized by SEM, XRD and XPS. Using the TLM alloy hydrothermally treated in deionized water as the control, the hy-drophilicity of the film was compared, and the antimicrobial properties were studied using the inhibition zone method. Results SEM, XRD and XPS analyses showed that the film consisting of TiO2 nanocrystals was formed on the surface of TLM alloy after the hydrothermal treatment. X-ray photoelectron spectroscopy analysis illustrated that Ti and Nb on sample surface existed as TiO2 and Nb2 O5 respectively, and Ag was in the metallic form. Contact angle measurement indicated that the treated sample had good photo-induced hydrophilicity, and the contact angle decreased from 108. to below 10. after 30 min of UV irradiation. In the antibacterial test, obvious inhibition zones against E. coli and S. aureus were observed for the treated sample after 24 h culture, and the inhibi-tion zone was wider against S. aureus. Conclusion Through hydrothermal treatment at 200 ℃ with 10 mmol/L of AgNO3 solution, Ag-containing TiO2 film with antimicrobial properties could be synthesized. The hydrothermal method to prepare Ag-containing TiO2 film in medical titanium alloy has the merits of easy operation, low processing temperature, evident antibacterial effect, etc.