糖尿病新世界
糖尿病新世界
당뇨병신세계
Diabetes New World
2015年
15期
82-84
,共3页
糖尿病肾病%ACEI类药物%ARB类药物%血管紧张素转换酶抑制剂
糖尿病腎病%ACEI類藥物%ARB類藥物%血管緊張素轉換酶抑製劑
당뇨병신병%ACEI류약물%ARB류약물%혈관긴장소전환매억제제
Diabetic nephropathy%ACEI%ARB%Angiotensin converting enzyme inhibitors
目的：探讨和分析血管紧张素转换酶抑制剂对于治疗糖尿病肾病的临床治疗效果。方法选取该院自2014年5月-2015年4月期间收治的106例患者作为研究对象，并把其随机分为两组，即观察组和对照组各53例，对照组给予贝那普利口服治疗；观察组采用缬沙坦与贝那普利联合治疗。之后对患者治疗前后和24 h内的尿蛋白值，以及血肌酶变化情况进行统计分析比较。结果经过6个月的治疗，观察组和对照组患者的尿蛋白值分别为0.310 g/L、0.525 g/L，均较治疗前有明显的改善，而两组患者尿蛋白值改善对比，差异有统计学意义(t=9.017, P<0.05)，观察组患者的血肌酐值为(140.33±37.98)μmol/L，明显低于对照组(132.30±43.05)μmol/L，该两组患者经治疗后的血肌酐值对比，差异有统计学意义(t=9.017, P<0.05)。结论对于糖尿病肾病患者，运用血管紧张素受体拮抗剂与转换酶抑制剂类药物进行联合用药治疗，有利于改善糖尿病患者的肾功能，其所起到的保护作用更加显著。
目的：探討和分析血管緊張素轉換酶抑製劑對于治療糖尿病腎病的臨床治療效果。方法選取該院自2014年5月-2015年4月期間收治的106例患者作為研究對象，併把其隨機分為兩組，即觀察組和對照組各53例，對照組給予貝那普利口服治療；觀察組採用纈沙坦與貝那普利聯閤治療。之後對患者治療前後和24 h內的尿蛋白值，以及血肌酶變化情況進行統計分析比較。結果經過6箇月的治療，觀察組和對照組患者的尿蛋白值分彆為0.310 g/L、0.525 g/L，均較治療前有明顯的改善，而兩組患者尿蛋白值改善對比，差異有統計學意義(t=9.017, P<0.05)，觀察組患者的血肌酐值為(140.33±37.98)μmol/L，明顯低于對照組(132.30±43.05)μmol/L，該兩組患者經治療後的血肌酐值對比，差異有統計學意義(t=9.017, P<0.05)。結論對于糖尿病腎病患者，運用血管緊張素受體拮抗劑與轉換酶抑製劑類藥物進行聯閤用藥治療，有利于改善糖尿病患者的腎功能，其所起到的保護作用更加顯著。
목적：탐토화분석혈관긴장소전환매억제제대우치료당뇨병신병적림상치료효과。방법선취해원자2014년5월-2015년4월기간수치적106례환자작위연구대상，병파기수궤분위량조，즉관찰조화대조조각53례，대조조급여패나보리구복치료；관찰조채용힐사탄여패나보리연합치료。지후대환자치료전후화24 h내적뇨단백치，이급혈기매변화정황진행통계분석비교。결과경과6개월적치료，관찰조화대조조환자적뇨단백치분별위0.310 g/L、0.525 g/L，균교치료전유명현적개선，이량조환자뇨단백치개선대비，차이유통계학의의(t=9.017, P<0.05)，관찰조환자적혈기항치위(140.33±37.98)μmol/L，명현저우대조조(132.30±43.05)μmol/L，해량조환자경치료후적혈기항치대비，차이유통계학의의(t=9.017, P<0.05)。결론대우당뇨병신병환자，운용혈관긴장소수체길항제여전환매억제제류약물진행연합용약치료，유리우개선당뇨병환자적신공능，기소기도적보호작용경가현저。
Objective To investigate and analyze the clinical effect of angiotensin converting enzyme inhibitor in treating diabetic nephropathy. Methods Selected in our hospital from 106 patients treated during April May 2014 to 2015 as the re-search object, and they were randomly divided into 2 groups, the observation group and control group of 53 cases, control group was given oral benazepril treatment; the observation group used valsartan combined with benazepril in the treatment. After treatment and 24 hours urine protein, and the changes of blood enzymes were statistically analyzed. Results After 6 months of treatment, the observation group and the control group, the urine protein values were 0.310g/L, 0.525g/L and were compared with those before treatment is significantly improved, and two groups of patients with proteinuria value to improve contrast, with obvious differences in (t=9.017, P < 0.05), the observation group of patients with serum creatinine values (140.33±37.98)μmol/L, significantly lower than the control group (132.30±43.05)μmol/L, the two groups of patients af-ter treatment, blood creatinine value comparison, have obvious difference, also has statistical significance (t=9.017, P <0.05). Conclusion in the patients with diabetic nephropathy using vascular tension endothelin receptor antagonist, and con-verting enzyme inhibitor (ACEI drug combination therapy, to improve renal function in patients with diabetes, they play a protective effect is more significant.
