CAJ | 학술논문

目的探讨层粘连蛋白(Laminin)与Ⅳ型胶原蛋白(Collagen Ⅳ)在宫颈原位癌与微小浸润癌鉴别诊断中的意义.方法应用免疫组化检测Laminin与CollagenⅣ在宫颈原位癌、微小浸润癌及浸润癌中的表达情况.结果 Laminin与Collagen Ⅳ的表达基本一致,两者在正常宫颈组织基底膜中呈完整连续性;原位癌中基底膜多数是连续性的,但着色深度不规则;微小浸润癌组基底膜呈不连续性,浸润癌组基底膜无着色,完全缺如.结论 Laminin与CollagenⅣ的表达不仅对原位癌与微小浸润癌的鉴别诊断有帮助,而且有助于预测原位癌发展为浸润癌.
목적 탐토층점련단백(Laminin)여Ⅳ형효원단백(Collagen Ⅳ)재궁경원위암여미소침윤암감별진단중적의의.방법 응용면역조화검측Laminin여CollagenⅣ재궁경원위암、미소침윤암급침윤암중적표체정황.결과 Laminin여Collagen Ⅳ적표체기본일치,량자재정상궁경조직기저막중정완정련속성;원위암중기저막다수시련속성적,단착색심도불규칙;미소침윤암조기저막정불련속성,침윤암조기저막무착색,완전결여.결론 Laminin여CollagenⅣ적표체불부대원위암여미소침윤암적감별진단유방조,이차유조우예측원위암발전위침윤암.
ObjectiveTo investigate the significance of laminin and collagen type IV in differential diagnosis between cervical carcinoma in situ and micro invasive carcinoma.MethodsImmunohistochemistry was performed to determine the expression laminin and collagen protein in cervical carcinoma in situ, microinvasive carcinoma and invasive carcinoma.ResultsExpressions of laminin and collagen IV located on the basement membrane continuously in normal cervical tissue; their expression is uninterrupted in most the basement membrane of ductal carcinoma in situ, but the color intensity is irregular; in microinvasive carcinoma group, the colouration of basement membrane was discontinuous; basement membrane staining was completely absent cervical cancer group. ConclusionThe expression of laminin and collagen IV could not only help to make diagnosis between carcinoma in situ and micro invasive carcinoma, but also could worked as a forecaster to predict the risk of developing invasive cancer.