CAJ | 학술논문

目的：分析曲伏前列素滴眼液治疗原发性开角型青光眼患者的临床疗效与安全性。方法收集2010年10月～2014年11月诊治的90例（180眼）原发性开角型青光眼患者作为研究对象，根据患者的治疗药物将其分为曲伏前列素滴眼液组（45例，90眼）与马来酸噻吗洛尔组（45例，90眼），马来酸噻吗洛尔组患者采用马来酸噻吗洛尔治疗，曲伏前列素滴眼液组采用曲伏前列素滴眼液，观察患者的总体治疗效果、不良反应发生率、治疗前后的视力、散光度改善情况以及治疗后不同时间的眼压改善情况。结果观察患者在视力变化、眼压变化、视野变化方面的整体治疗效果发现，曲伏前列素滴眼液组明显优于马来酸噻吗洛尔组（ P＜0．05）；同时，曲伏前列素滴眼液组不良反应发生率明显低于马来酸噻吗洛尔组（ P＜0．05）；且曲伏前列素滴眼液组患者的治疗前后的视力、散光度改善情况以及治疗后不同时间的眼压改善情况明显优于马来酸噻吗洛尔组（ P＜0．05）。结论曲伏前列素滴眼液治疗原发性开角型青光眼患者具有良好的临床疗效，并具有很高的安全性。
목적：분석곡복전렬소적안액치료원발성개각형청광안환자적림상료효여안전성。방법수집2010년10월～2014년11월진치적90례（180안）원발성개각형청광안환자작위연구대상，근거환자적치료약물장기분위곡복전렬소적안액조（45례，90안）여마래산새마락이조（45례，90안），마래산새마락이조환자채용마래산새마락이치료，곡복전렬소적안액조채용곡복전렬소적안액，관찰환자적총체치료효과、불량반응발생솔、치료전후적시력、산광도개선정황이급치료후불동시간적안압개선정황。결과관찰환자재시력변화、안압변화、시야변화방면적정체치료효과발현，곡복전렬소적안액조명현우우마래산새마락이조（ P＜0．05）；동시，곡복전렬소적안액조불량반응발생솔명현저우마래산새마락이조（ P＜0．05）；차곡복전렬소적안액조환자적치료전후적시력、산광도개선정황이급치료후불동시간적안압개선정황명현우우마래산새마락이조（ P＜0．05）。결론곡복전렬소적안액치료원발성개각형청광안환자구유량호적림상료효，병구유흔고적안전성。
Objective To analysis of clinical efficacy and safety of travoprost eye drops in treatment of patients with primary open-angle glaucoma.Methods To collected from October 2010 to November 2014 during the diagnosis and treatment of 90 cases (180 eyes) with primary open-angle glaucoma patients as the research object, according to the treatment of patients with drugs will be divided into the travoprost eye drops group (45 cases, 90 eyes) with travoprost and Timclol Maleate group (45 cases, 90 eyes),with Timclol Maleate.Patients using timclol maleate therapy in Timclol Maleate group, travoprost eye drops group adopted travoprost, observing the patient′s overall treatment effect, the inci-dence of adverse reactions, eyesight, photometric before and after treatment as well as the improved situation of intraocu-lar pressure in different time after treatment.Results To observe the patients′changes in visual acuity, intraocular pressure, vision changes in terms of the overall treatment effect is found, travoprost is obviously better than the other eye drops group Timclol Maleate group ( P<0.05 ); At the same time, travoprost eye drops group significantly lower inci-dence of adverse reactions of Timclol Maleate group ( P<0.05);And travoprost eye drops group before and after treat-ment in patients with vision, improve luminosity and intraocular pressure improved obviously in different time after treat-ment is better than that of Timclol Maleate group ( P<0.05 ) .Conclusions Ttravoprost eye drops in the treatment of primary open-angle glaucoma patients has good clinical curative effect and very high security.