CAJ | 학술논문

目的探讨外周T细胞淋巴瘤(PTCL)继发弥漫大B细胞淋巴瘤(DLBCL)的诊治方法.方法报道1例PTCL继发DLBCL病例的诊治经过,分析该例患者的临床特点、治疗反应,复习文献探讨该类疾病的机制及预后.结果患者诊断PTCL非特指型(PTCL-NOS)明确,治疗后出现以EB病毒(EBV)阴性DLBCL为表现的第二肿瘤,其临床特点及发病间隔与之前国外报道类似,可能涉及肿瘤细胞、微环境及治疗等多方面因素.该例患者初步治疗有效,有待进一步随访观察.结论 PTCL-NOS继发EBV阴性DLBCL非常罕见,发病机制和治疗效果有待进一步探索.
목적 탐토외주T세포림파류(PTCL)계발미만대B세포림파류(DLBCL)적진치방법.방법 보도1례PTCL계발DLBCL병례적진치경과,분석해례환자적림상특점、치료반응,복습문헌탐토해류질병적궤제급예후.결과 환자진단PTCL비특지형(PTCL-NOS)명학,치료후출현이EB병독(EBV)음성DLBCL위표현적제이종류,기림상특점급발병간격여지전국외보도유사,가능섭급종류세포、미배경급치료등다방면인소.해례환자초보치료유효,유대진일보수방관찰.결론 PTCL-NOS계발EBV음성DLBCL비상한견,발병궤제화치료효과유대진일보탐색.
Objective To investigate the diagnosis and treatment of sequential diffuse large B-cell lymphoma (DLBCL) after peripheral T-cell lymphoma (PTCL).Methods A case with sequential DLBCL after PTCL was reported,and the characteristics and responses of this case were analyzed.The previous literature was reviewed in order to explain the mechanism and prognosis of such type of disease.Results This patient was diagnosed as PTCL not otherwise specified (PTCL-NOS) definitely,but after a period of treatment,DLBCL was developed as a second tumor.The characteristics and onset interval were just similar to those described in the literature,in which the mechanisms were mentioned as common effects of tumor cell,microenviroment and therapies.This patient got effects through the initial treatment,but considering the poor outcome by former researchers,the prognosis needed to be closely followed up.Conclusion Sequential development of EBV-unrelated DLBCL after PTCL-NOS is very rare,and the mechanism,therapy and prognosis need further investigation.