CAJ | 학술논문

目的：观察盐酸多奈哌齐联合美金刚对阿尔茨海默病患者认知及生活能力的改善作用。方法将阿尔茨海默病患者48例按随机数字表法分为2组，各24例。对照组接受盐酸多奈哌齐治疗，观察组接受盐酸多奈哌齐联合美金刚治疗，疗程12周，每4周进行1次随访。治疗前后采用阿尔茨海默病评价量表—认知分量表（ ADAS-cog）、神经精神科问卷（NPI）、日常生活能力量表（ADL）、痴呆行为量表（BEHAVE-AD）、简明智能量表（MMSE）对患者进行评估，并观察不良反应发生情况。结果2组患者治疗前各项评分差异无统计学意义（ P ＞0ú．05）。治疗12周后，观察组与对照组的ADAS-cog评分、NPI评分、ADL评分、BEHAVE-AD评分均有所下降（ P ＜0．05），MMSE评分均有上升（ P ＜0．05），且观察组各表评分改善较对照组更明显，2组比较差异均有统计学意义（ P ＜0．05）。对照组发生不良反应2例（8．33％），观察组未见明确不良反应。结论盐酸多奈哌齐联合美金刚对阿尔茨海默病患者的认知及生活能力有明显改善作用，治疗效果优于单用盐酸多奈哌齐治疗。
목적：관찰염산다내고제연합미금강대아이자해묵병환자인지급생활능력적개선작용。방법장아이자해묵병환자48례안수궤수자표법분위2조，각24례。대조조접수염산다내고제치료，관찰조접수염산다내고제연합미금강치료，료정12주，매4주진행1차수방。치료전후채용아이자해묵병평개량표—인지분량표（ ADAS-cog）、신경정신과문권（NPI）、일상생활능역량표（ADL）、치태행위량표（BEHAVE-AD）、간명지능량표（MMSE）대환자진행평고，병관찰불량반응발생정황。결과2조환자치료전각항평분차이무통계학의의（ P ＞0ú．05）。치료12주후，관찰조여대조조적ADAS-cog평분、NPI평분、ADL평분、BEHAVE-AD평분균유소하강（ P ＜0．05），MMSE평분균유상승（ P ＜0．05），차관찰조각표평분개선교대조조경명현，2조비교차이균유통계학의의（ P ＜0．05）。대조조발생불량반응2례（8．33％），관찰조미견명학불량반응。결론염산다내고제연합미금강대아이자해묵병환자적인지급생활능력유명현개선작용，치료효과우우단용염산다내고제치료。
Objective To observe the effect of donepezil hydrochloride combined with memantine on cognitive andlife ability of patients with Alzheimer's disease.Methods Forty-eight cases of Alzheimer's disease patients were randomly dividedinto 2 groups, 24 cases in each group.The control group was treated with donepezil hydrochloride , in observationgroup, patients were treated with donepezil hydrochloride combined with memantine treatment for 12 weeks, follow up werecarried out at every 4 weeks.Before and after treatment, Alzheimer disease assessment scale-cognitive component table(ADAS-cog), Neuropsychiatric Inventory (NPI), ability of daily life table (ADL), dementia behavior table (BEHAVEAD),Mini Mental Scale (MMSE) were used to assess these patients, and observed the occurrence of adverse reactions .Results There were no significant differences of these index score between the 2 groups before treatment ( P >0.05).After 12weeks of treatment, ADAS-cog score and NPI score and ADL score, BEHAVE-AD score were decreased in both of observationgroup and control group ( P <0.05), MMSE score were increased ( P <0.05), and the observation group’s each tablescores were improved more significantly than in the control group , the differences between the two groups were statistically sig -nificant ( P <0.05).There were 2 cases (8.33%) in the control group occurred with adverse reactions ; the observationgroup had no adverse reactions.Conclusion Donepezil hydrochloride combined with memantine has obviously improvementeffect in patients with Alzheimer's disease cognition and ability of daily living , which were better than single usage of donepezilhydrochloride.