CAJ | 학술논문

目的：探讨玻璃酸钠关节腔内注射与中药补肾强骨方联用对于膝骨性关节炎（KOA ）患者血清炎性因子水平的影响。方法：将124例KOA患者随机分为观察组与对照组，每组62例。对照组予以玻璃酸钠经膝关节腔内注射，观察组在对照组的基础上加用中药补肾强骨方口服，比较两组的疗效及血清炎性因子水平变化。结果：观察组的治疗总有效率为96．77％，显著高于对照组的85．48％（ P＜0．05）；治疗后观察组的中医证候评分及血清炎性因子（IL‐1、TNF‐α及hs‐CRP）水平均显著低于对照组（P＜0．05）。结论：玻璃酸钠关节腔内注射联合补肾强骨方内服治疗KOA能够有效降低炎性因子水平，从而改善临床症状并提高临床疗效，值得推广应用。
목적：탐토파리산납관절강내주사여중약보신강골방련용대우슬골성관절염（KOA ）환자혈청염성인자수평적영향。방법：장124례KOA환자수궤분위관찰조여대조조，매조62례。대조조여이파리산납경슬관절강내주사，관찰조재대조조적기출상가용중약보신강골방구복，비교량조적료효급혈청염성인자수평변화。결과：관찰조적치료총유효솔위96．77％，현저고우대조조적85．48％（ P＜0．05）；치료후관찰조적중의증후평분급혈청염성인자（IL‐1、TNF‐α급hs‐CRP）수평균현저저우대조조（P＜0．05）。결론：파리산납관절강내주사연합보신강골방내복치료KOA능구유효강저염성인자수평，종이개선림상증상병제고림상료효，치득추엄응용。
Objective :To explore the combined for knee osteoarthritis and intra‐articular injection of sodium hyalur‐onate and traditional Chinese medicine Bushenqianggu decotion (KOA) affect the level of serum inflammatory factors in patients with .Methods :124 cases of KOA patients were randomly divided into observation group and control group ,62 cases in each group .Control group was treated with sodium hyaluronate after intra‐articular injection ,the observation group based on the use of Chinese medicine Bushenqianggu decoction ,curative effect and the changes of serum levels of inflammatory factors were compared between the two groups .Results:The total effective rate of observation group was 96 .77% ,significantly higher than the control group 85 .48% (P<0 .05);the observation group after treatment of TCM syndrome score and serum inflammatory factor (IL‐1 ,TNF‐α and hs‐CRP)was significantly lower than the control group (P<0 .05) .Conclusion:Intraarticular injection of sodium hyaluronate combined Bushenqianggu oral treatment of KOA can effectively reduce the levels of inflammatory factors ,so as to improve the clinical symptoms and improve the clinical efficacy ,it is worthy of popularization and application .