中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
18期
61-62,63
,共3页
雷洛昔芬%克罗米芬%多囊卵巢综合征%促排卵
雷洛昔芬%剋囉米芬%多囊卵巢綜閤徵%促排卵
뢰락석분%극라미분%다낭란소종합정%촉배란
raloxifene%clomiphene%polycystic ovary syndrome%ovulation induction
目的：比较雷洛昔芬与克罗米芬治疗多囊卵巢综合征（PCOS）的临床疗效及对排卵的促进作用。方法将86例患者随机分为A组和B组，各43例。A组和B组分别于月经第5天给予雷洛昔芬和克罗米芬治疗。月经第12天通过B超检查监测卵泡及子宫内膜情况，当卵泡直径超过18 mm、子宫内膜厚度超过7 mm时，肌肉注射人绒毛膜促性腺激素（HCG）5000~10000 U诱发排卵。结果 HCG注射日A组患者子宫内膜厚度明显高于B组（ P﹤0.05）；与B组相比，A组雌二醇（E2）、促黄体生成素（LH）均有明显改善（ P﹤0.05）；HCG注射48 h后，A组排卵率明显高于B组（ P﹤0.05）；两组患者成熟卵泡数量、卵泡成熟时间相当（ P﹥0.05）；两组患者不良反应发生率均较低，差异无统计学意义（ P﹥0.05）。结论雷洛昔芬能改善PCOS患者的性激素指标，对子宫内膜不良反应较小，具有较好的促排卵作用，且临床不良反应较少，安全性较高，值得进一步研究。
目的：比較雷洛昔芬與剋囉米芬治療多囊卵巢綜閤徵（PCOS）的臨床療效及對排卵的促進作用。方法將86例患者隨機分為A組和B組，各43例。A組和B組分彆于月經第5天給予雷洛昔芬和剋囉米芬治療。月經第12天通過B超檢查鑑測卵泡及子宮內膜情況，噹卵泡直徑超過18 mm、子宮內膜厚度超過7 mm時，肌肉註射人絨毛膜促性腺激素（HCG）5000~10000 U誘髮排卵。結果 HCG註射日A組患者子宮內膜厚度明顯高于B組（ P﹤0.05）；與B組相比，A組雌二醇（E2）、促黃體生成素（LH）均有明顯改善（ P﹤0.05）；HCG註射48 h後，A組排卵率明顯高于B組（ P﹤0.05）；兩組患者成熟卵泡數量、卵泡成熟時間相噹（ P﹥0.05）；兩組患者不良反應髮生率均較低，差異無統計學意義（ P﹥0.05）。結論雷洛昔芬能改善PCOS患者的性激素指標，對子宮內膜不良反應較小，具有較好的促排卵作用，且臨床不良反應較少，安全性較高，值得進一步研究。
목적：비교뢰락석분여극라미분치료다낭란소종합정（PCOS）적림상료효급대배란적촉진작용。방법장86례환자수궤분위A조화B조，각43례。A조화B조분별우월경제5천급여뢰락석분화극라미분치료。월경제12천통과B초검사감측란포급자궁내막정황，당란포직경초과18 mm、자궁내막후도초과7 mm시，기육주사인융모막촉성선격소（HCG）5000~10000 U유발배란。결과 HCG주사일A조환자자궁내막후도명현고우B조（ P﹤0.05）；여B조상비，A조자이순（E2）、촉황체생성소（LH）균유명현개선（ P﹤0.05）；HCG주사48 h후，A조배란솔명현고우B조（ P﹤0.05）；량조환자성숙란포수량、란포성숙시간상당（ P﹥0.05）；량조환자불량반응발생솔균교저，차이무통계학의의（ P﹥0.05）。결론뢰락석분능개선PCOS환자적성격소지표，대자궁내막불량반응교소，구유교호적촉배란작용，차림상불량반응교소，안전성교고，치득진일보연구。
Objective To compare the clinical efficacy and safety of raloxifene and clomiphene in treating polycystic ovary syndrome ( PCOS ) . Methods Totally 86 patients were randomly divided into group A and the group B,43 cases in each group. The group B were given clomiphene,and the group A was given raloxifene on the 5th day of menstruation. On the 12th day of menstruation,the con-dition of follicular and endometrial were checked by B-ultrasound;when the follicle diameter ﹥ 18 mm,and the endometrial thickness ﹥ 7 mm, the intramuscular injection of human chorionic gonadotropin(HCG) 5 000~10 000 U was applied to induce ovulation. Results The endometrial thickness of group A on the HCG injection day was higher than the group B( P ﹤ 0. 05);the E2 and LH levels of group A improved better than group B( P ﹤ 0. 05);after 48 h of HCG injection,the ovulation rate of group A was significantly higher than group B( P ﹤ 0. 05);the number of mature follicles,follicle considerable time of the two groups had no statistically significant dif-ference( P ﹥ 0. 05);the occurrence rate of adverse reactions in the two groups had no statistical differences( P ﹥ 0. 05). Conclusion Raloxifene can improve hormone index of PCOS patients with fewer adverse reactions on the endometrium,it is safe and has a good role in promoting ovulation,and deserves to be further studied.
