CAJ | 학술논문

目的：探讨胱抑素C、糖化血红蛋白及β2微球蛋白检测糖尿病早期肾损伤的诊断价值。方法选择自2013年4月—2015年2月收治的无肾损伤的糖尿病患者20例、糖尿病肾病患者20例及健康体检者20例分别纳入糖尿病组、糖尿病肾病组、对照组。检测并比较3组受试者的探讨胱抑素C、糖化血红蛋白及β2微球蛋白水平及阳性率。结果胱抑素C、β2微球蛋白水平及阳性率按照对照组、糖尿病组、糖尿病肾病组依次升高，差异有统计学意义(P<0.05)。糖尿病组糖化血红蛋白水平及阳性率与糖尿病肾病比较差异不大，但均高于对照组(P<0.05)。结论糖化血红蛋白检测异常的情况下，胱抑素C、β2微球蛋白可作为可预测糖尿病早期肾损害的良好指标。
목적：탐토광억소C、당화혈홍단백급β2미구단백검측당뇨병조기신손상적진단개치。방법선택자2013년4월—2015년2월수치적무신손상적당뇨병환자20례、당뇨병신병환자20례급건강체검자20례분별납입당뇨병조、당뇨병신병조、대조조。검측병비교3조수시자적탐토광억소C、당화혈홍단백급β2미구단백수평급양성솔。결과광억소C、β2미구단백수평급양성솔안조대조조、당뇨병조、당뇨병신병조의차승고，차이유통계학의의(P<0.05)。당뇨병조당화혈홍단백수평급양성솔여당뇨병신병비교차이불대，단균고우대조조(P<0.05)。결론당화혈홍단백검측이상적정황하，광억소C、β2미구단백가작위가예측당뇨병조기신손해적량호지표。
Objective To investigate cystatin C, glycosylated hemoglobin, and beta 2 microglobulinulin for diagnostic value of detection of diabetes early renal damage. Methods Electing 20 cases with diabetic, 20 patients with diabetic nephropa-thy, and 20 healthy cases from April 2013 to February 2015 check-up in diabetes and diabetic nephropathy group and control group respectively.Test and compare the three groups of cystatin C, glycosylated hemoglobin, and beta 2 microglobu-linulin levels and the positive rate. Results cystatin C, beta 2 microglobulinulin level and positive rate in accordance with the control group, diabetes group, diabetic nephropathy, in turn, increases, the difference was statistically significant (P <0.05).Glycated hemoglobin levels and diabetes group were compared with diabetic nephropathy, difference is not big, but were higher than control group(P<0.05). Conclusion When abnormal glycosylated hemoglobin level, cystatin C, beta 2 mi-croglobulin can as a can predict a good indicator of diabetes early renal damage.