中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
18期
39-40,41
,共3页
体外循环%磷酸肌酸%心肌保护
體外循環%燐痠肌痠%心肌保護
체외순배%린산기산%심기보호
cardiopulmonary bypass%creatine phosphate%myocardial preservation
目的：探讨磷酸肌酸在体外循环心脏手术中对心肌保护的临床疗效。方法将2011年1月至2014年1月在医院行心脏手术的80例患者按随机数字表法分为观察组和对照组，各40例。观察组患者在冷血停搏液中加入磷酸肌酸，对照组患者则不加。结果观察组术后的心肌酶指标水平均显著低于对照组（ P﹤0.05）；观察组的自动复跳率显著高于对照组，应用血管活性药的比率显著低于对照组，差异均有统计学意义（ P﹤0.05）；观察组患者出院时、出院3个月后心功能Lown分级0~Ⅰ级及Ⅱ~Ⅲ级比率，均显著高于对照组患者（ P﹤0.05）。结论在体外循环心脏手术中加用磷酸肌酸，可有效促进心肌功能恢复，增强心脏停搏液的保护作用，防止发生心律失常，确保手术疗效，值得临床推广。
目的：探討燐痠肌痠在體外循環心髒手術中對心肌保護的臨床療效。方法將2011年1月至2014年1月在醫院行心髒手術的80例患者按隨機數字錶法分為觀察組和對照組，各40例。觀察組患者在冷血停搏液中加入燐痠肌痠，對照組患者則不加。結果觀察組術後的心肌酶指標水平均顯著低于對照組（ P﹤0.05）；觀察組的自動複跳率顯著高于對照組，應用血管活性藥的比率顯著低于對照組，差異均有統計學意義（ P﹤0.05）；觀察組患者齣院時、齣院3箇月後心功能Lown分級0~Ⅰ級及Ⅱ~Ⅲ級比率，均顯著高于對照組患者（ P﹤0.05）。結論在體外循環心髒手術中加用燐痠肌痠，可有效促進心肌功能恢複，增彊心髒停搏液的保護作用，防止髮生心律失常，確保手術療效，值得臨床推廣。
목적：탐토린산기산재체외순배심장수술중대심기보호적림상료효。방법장2011년1월지2014년1월재의원행심장수술적80례환자안수궤수자표법분위관찰조화대조조，각40례。관찰조환자재랭혈정박액중가입린산기산，대조조환자칙불가。결과관찰조술후적심기매지표수평균현저저우대조조（ P﹤0.05）；관찰조적자동복도솔현저고우대조조，응용혈관활성약적비솔현저저우대조조，차이균유통계학의의（ P﹤0.05）；관찰조환자출원시、출원3개월후심공능Lown분급0~Ⅰ급급Ⅱ~Ⅲ급비솔，균현저고우대조조환자（ P﹤0.05）。결론재체외순배심장수술중가용린산기산，가유효촉진심기공능회복，증강심장정박액적보호작용，방지발생심률실상，학보수술료효，치득림상추엄。
Objective To investigate the clinical effect of creatine phosphate for the myocardial protection in cardiopulmonary bypass surgery. Methods 80 patients undergoing cardiac surgery in the hospital from January 2011 to January 2014 were divided into the ob-servation group( n=40)and the control group( n=40)according to the random number table method. The observation group added cre-atine phosphate in cold blood cardioplegia,while the control group did not. The myocardial protective effects were compared between the two groups. Results The postoperative levels of myocardial enzyme indexes in the observation group were significantly lower than those in the control group( P ﹤ 0. 05);the auto-rebeat rate of the observation group was significantly higher than that of the control group, and the ratio of vasoactive drug application was significantly lower than that of the control group,all the differences were statistically significant( P ﹤ 0. 05);the percentage of patients with cardiac function Lown grade 0-Ⅰand Ⅱ-Ⅲ in the observation group at dis-charge and 3 months after discharge was significantly higher than that in the control group( P ﹤ 0. 05). Conclusion Adding creatine phosphate in the open-heart surgery can effectively promote the recovery of myocardial function,enhance the protective effect of car-dioplegic solution,prevent the occurrence of arrhythmia,ensure the operation curative effect,and is worth of clinical promotion.
