CAJ | 학술논문

目的：探讨前列地尔联合小剂量多巴胺治疗小儿慢性肾功能不全的临床效果。方法随机选择2012年1月-2013年6月收治的80例小儿慢性肾功能不全患者随机分为观察组与对照组，每组40例。对照组在常规基础治疗的基础上给予20 mg多巴胺+200 mL生理盐水按照0.5~2μg/kg·min水平进行静脉滴注；观察组给予20 mg多巴胺+200 mL生理盐水并联用20μg前列地尔+100 mL生理盐水静脉滴注，8周为1个疗程。比较两组患儿血肌酐(SCr)、内生肌酐清除率(CCr)及尿素氮(BUN)等肾功能指标变化，并记录不良反应发生情况。结果观察组血肌酐(SCr)、内生肌酐清除率(CCr)及尿素氮(BUN)各项指标较对照组明显改善（P<0.05），且总有效率达95%远高于对照组60%水平，两组不良反应发生情况差异无统计学意义。结论前列地尔联合小剂量多巴胺治疗小儿慢性肾功能不全，有效改善患儿肾功能，且副作用小，有效延缓肾功能衰竭。
목적：탐토전렬지이연합소제량다파알치료소인만성신공능불전적림상효과。방법수궤선택2012년1월-2013년6월수치적80례소인만성신공능불전환자수궤분위관찰조여대조조，매조40례。대조조재상규기출치료적기출상급여20 mg다파알+200 mL생리염수안조0.5~2μg/kg·min수평진행정맥적주；관찰조급여20 mg다파알+200 mL생리염수병련용20μg전렬지이+100 mL생리염수정맥적주，8주위1개료정。비교량조환인혈기항(SCr)、내생기항청제솔(CCr)급뇨소담(BUN)등신공능지표변화，병기록불량반응발생정황。결과관찰조혈기항(SCr)、내생기항청제솔(CCr)급뇨소담(BUN)각항지표교대조조명현개선（P<0.05），차총유효솔체95%원고우대조조60%수평，량조불량반응발생정황차이무통계학의의。결론전렬지이연합소제량다파알치료소인만성신공능불전，유효개선환인신공능，차부작용소，유효연완신공능쇠갈。
Objective To explore the effect of alprostadil combined with low-dose dopamine for treatment on chronic renal insuf-ficiency. Methods 40 case of CRI from 2012 January to 2013 June was randomly divided into observer and control groups, each with 20 cases. The observer group was given 20μg alprostadil+200 ml0.9%NS combined with 20 mg dopamine+200 mL0.9%NS iv for 8 weeks. The control group was give 20 mg dopamine+200 mL0.9%NS iv for 8 weeks. The SCr, CCr, BUN were measured and compared with two groups. Meanwhile the curative effect analysis of two group were compared. Results The SCr, CCr, BUN of ob-server group after measurement were significantly better than the control group, and the curative effect of observer group was high-er than the control group. Conclusion The low-dose dopamine combined with alprostadil in treatment of chronic renal insufficien-cy is efficacy,decrease in development which is worthy to be used in clinical treatment.