CAJ | 학술논문

目的：探讨不同剂量地佐辛静点辅助罗哌卡因用于术后患者硬膜外自控镇痛的镇痛效果和副作用的差异。方法随机选择2014年5月-2015年4月该院收治的90例择期妇科下腹部开腹手术患者，随机分为3组,每组30例，Ⅰ组地佐辛0.0075 mg·(kg·h)-1,Ⅱ组地佐辛0.0075 mg·(kg·h)-1辅助0.2%甲磺酸罗哌卡因硬膜外镇痛，Ⅲ组地佐辛0.01 mg·(kg·h)-1辅助0.2%甲磺酸罗哌卡因硬膜外镇痛，3组地佐辛均为静点，Ⅱ组、Ⅲ组术毕硬膜外腔给予0.2%甲磺酸罗哌卡因负荷量后接镇痛泵,观察术后2、6、12、24、36、48 h的ECG、SPO2、RR、BP疼痛及镇静评分并记录恶心呕吐瘙痒等不良反应。结果3组患者镇静评分差异无统计学意义，疼痛评分（VAS）Ⅱ组和Ⅲ组均显著低于Ⅰ组，差异有统计学意义﹙P<0.05﹚,3组恶心呕吐等不良反应的发生率Ⅲ组高于Ⅰ组和Ⅱ组，差异有统计学意义（P<0.05）。结论地佐辛静点0.0075 mg·(kg·h)-1辅助0.2%甲磺酸罗哌卡因硬膜外镇痛,副反应的发生率低又能取得更好的术后镇痛效果。
목적：탐토불동제량지좌신정점보조라고잡인용우술후환자경막외자공진통적진통효과화부작용적차이。방법수궤선택2014년5월-2015년4월해원수치적90례택기부과하복부개복수술환자，수궤분위3조,매조30례，Ⅰ조지좌신0.0075 mg·(kg·h)-1,Ⅱ조지좌신0.0075 mg·(kg·h)-1보조0.2%갑광산라고잡인경막외진통，Ⅲ조지좌신0.01 mg·(kg·h)-1보조0.2%갑광산라고잡인경막외진통，3조지좌신균위정점，Ⅱ조、Ⅲ조술필경막외강급여0.2%갑광산라고잡인부하량후접진통빙,관찰술후2、6、12、24、36、48 h적ECG、SPO2、RR、BP동통급진정평분병기록악심구토소양등불량반응。결과3조환자진정평분차이무통계학의의，동통평분（VAS）Ⅱ조화Ⅲ조균현저저우Ⅰ조，차이유통계학의의﹙P<0.05﹚,3조악심구토등불량반응적발생솔Ⅲ조고우Ⅰ조화Ⅱ조，차이유통계학의의（P<0.05）。결론지좌신정점0.0075 mg·(kg·h)-1보조0.2%갑광산라고잡인경막외진통,부반응적발생솔저우능취득경호적술후진통효과。
Objective To observe different doses of dezocine intravenous assisted ropivacaine for analgesia in patients between epidural analgesia and postoperative side effects. Methods In 2014 May-2015 year in April 90 cgynecological abdominal opera-tion were randomly divided into three groups, 30 cases in each group, one group of dezocine 0.0075 mg·(kg·h)-1 II group, de-zocine 0.0075 mg·(kg·h)-1 0.2%ropivacaine for epidural analgesia group, dezocine 0.01 mg·(kg·h)-1 0.2% a Ropivacaine Mesy-late epidural analgesia, 3 groups were intravenous dezocine, group II, group III postoperative epidural 0.2% Ropivacaine Mesylate load after analgesia pump, observed after 2, 6, 12, 24, 36, 48 h, ECG, SPO2, RR, BP pain and sedation scores and record the ad-verse reaction of nausea and vomiting. Results Three patients with no significant sedation score, pain score (VAS) in group II and III group were significantly lower than those of group I, was statistically significant (P<0.05), three groups of side reactions such as nausea and vomiting incidence of III group was higher than that of group I and group II were statistically significant (P<0.05). Conclusion Dezocine intravenous 0.0075 mg·(kg·h)-1 0.2%ropivacaine for epidural analgesia, analgesic effect of side reaction rate is low and can get better after operation.