中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
24期
103-104,107
,共3页
轮状病毒感染%免疫应答%儿童
輪狀病毒感染%免疫應答%兒童
륜상병독감염%면역응답%인동
Rotavirus%Immune response%Children
目的：对小儿轮状病毒感染的免疫应答进行研究。方法以该院2014年1月-2015年3月收治的62例轮状病毒感染患儿作为观察组，以同期在该院进行健康体检的60例小儿作为对照组，对比两组研究对象的抗原及粪便标本与血浆中的特异性抗体，并检测轮状病毒基因类型。结果观察组62例患儿的粪标本中的轮状病毒分型P型中Ps型所占比例最高，为82.26%，G分型中以G3所占比例最高，为79.03%，P<0.05，差异具有统计学意义。观察组患儿的CD19+细胞比例明显高于对照组，CD4+比例明显低于对照组，P<0.05，差异具有统计学意义。同对照组相比，观察组患儿的外周血单个核细胞IFN-γmRNA表达水平在发病3 d内出现明显升高，P<0.05，差异具有统计学意义。IL-12p40 mRNA在疾病构成中均明显高于对照组，P<0.05，差异具有统计学意义。结论轮状病毒感染患儿的免疫应答中以特异性体液免疫为主，特别是黏膜免疫显著性增强。
目的：對小兒輪狀病毒感染的免疫應答進行研究。方法以該院2014年1月-2015年3月收治的62例輪狀病毒感染患兒作為觀察組，以同期在該院進行健康體檢的60例小兒作為對照組，對比兩組研究對象的抗原及糞便標本與血漿中的特異性抗體，併檢測輪狀病毒基因類型。結果觀察組62例患兒的糞標本中的輪狀病毒分型P型中Ps型所佔比例最高，為82.26%，G分型中以G3所佔比例最高，為79.03%，P<0.05，差異具有統計學意義。觀察組患兒的CD19+細胞比例明顯高于對照組，CD4+比例明顯低于對照組，P<0.05，差異具有統計學意義。同對照組相比，觀察組患兒的外週血單箇覈細胞IFN-γmRNA錶達水平在髮病3 d內齣現明顯升高，P<0.05，差異具有統計學意義。IL-12p40 mRNA在疾病構成中均明顯高于對照組，P<0.05，差異具有統計學意義。結論輪狀病毒感染患兒的免疫應答中以特異性體液免疫為主，特彆是黏膜免疫顯著性增彊。
목적：대소인륜상병독감염적면역응답진행연구。방법이해원2014년1월-2015년3월수치적62례륜상병독감염환인작위관찰조，이동기재해원진행건강체검적60례소인작위대조조，대비량조연구대상적항원급분편표본여혈장중적특이성항체，병검측륜상병독기인류형。결과관찰조62례환인적분표본중적륜상병독분형P형중Ps형소점비례최고，위82.26%，G분형중이G3소점비례최고，위79.03%，P<0.05，차이구유통계학의의。관찰조환인적CD19+세포비례명현고우대조조，CD4+비례명현저우대조조，P<0.05，차이구유통계학의의。동대조조상비，관찰조환인적외주혈단개핵세포IFN-γmRNA표체수평재발병3 d내출현명현승고，P<0.05，차이구유통계학의의。IL-12p40 mRNA재질병구성중균명현고우대조조，P<0.05，차이구유통계학의의。결론륜상병독감염환인적면역응답중이특이성체액면역위주，특별시점막면역현저성증강。
Objective To study the immune response to rotavirus infections in Children. Methods 62 children with rotavirus infec-tions admitted to our hospital and 60 other children who taken physical examination here between January 2014 and March 2015 were assigned to observation group and control group respectively to compare the antigen and the specific antibodies in feces and plasma between the two groups and determine the gene types of rotavirus. Results In the observation group, in P and G type ro-tavirus from feces specimens, P8-type and G3-type were most prominent, accounting for 82.26% and 79.03%, respectively, and the differences were statistically significant, P<0.05. The proportion of CD19+Cells were higher and that of CD4+lower in the ob-servation group than in the control group, and the differences were statistically significant, P<0.05. Compared with the control group, IFN-γ, and mRNA expression in peripheral blood mononuclear cells in the observation group increased significantly within 3 days after onset, and the difference was statistically significant,P<0.05. IL-12p40 and mRNA in the diseases constitution were higher in the observation group than in the control group with statistical differences, P<0.05. Conclusion Immune response to ro-tavirus infections in children is mainly specific humoral immune response, especially that of mucosal immune.
