CAJ | 학술논문

【目的】探讨氟哌啶醇短期治疗对精神分裂症患者脑涨落图相关检测指标的影响。【方法】选择2014年12月至2015年5月本院收治的29例精神分裂症患者，d1肌注氟哌啶醇5 mg ，2次／天，d2～6肌注氟哌啶醇5 mg ，3次／天，总疗程共计6 d。分别于治疗前、治疗后采用SP03脑涨落图仪检测所有研究对象相关脑功能参数，记录治疗前及治疗后患者匹兹堡睡眠质量指数（PSQI），并评定阳性症状和阴性症状评定量表（PANSS）。【结果】治疗前后患者的9种神经递质全脑功率与治疗前相比无显著性差异（ P ＞0．05）；治疗后去甲肾上腺素（NE）的相对功率和血管舒缩指数明显低于治疗前（ P ＜0．05）；与治疗前相比，治疗后患者的PANSS与 PSQI评分明显下降（ P ＜0．05）。【结论】氟哌啶醇短期疗法治疗精神分裂症的疗效可能是与降低NE功能有关，脑涨落图仪能检测脑内多种递质功能，在探索患者神经生化机制研究、抗精神病药物作用机制及疗效的监测方面可以发挥较好的作用。
【목적】탐토불고정순단기치료대정신분렬증환자뇌창락도상관검측지표적영향。【방법】선택2014년12월지2015년5월본원수치적29례정신분렬증환자，d1기주불고정순5 mg ，2차／천，d2～6기주불고정순5 mg ，3차／천，총료정공계6 d。분별우치료전、치료후채용SP03뇌창락도의검측소유연구대상상관뇌공능삼수，기록치료전급치료후환자필자보수면질량지수（PSQI），병평정양성증상화음성증상평정량표（PANSS）。【결과】치료전후환자적9충신경체질전뇌공솔여치료전상비무현저성차이（ P ＞0．05）；치료후거갑신상선소（NE）적상대공솔화혈관서축지수명현저우치료전（ P ＜0．05）；여치료전상비，치료후환자적PANSS여 PSQI평분명현하강（ P ＜0．05）。【결론】불고정순단기요법치료정신분렬증적료효가능시여강저NE공능유관，뇌창락도의능검측뇌내다충체질공능，재탐색환자신경생화궤제연구、항정신병약물작용궤제급료효적감측방면가이발휘교호적작용。
[Objective] To explore the effects of brief haloperidol therapy on the encephalofluctuograph (EFG) index in schizophrenia patients .[Methods]During December 2014 and May 2015 ,a total of 35 hospitalized schizo‐phrenics received an intramuscular injection of haloperidol .At Day 1 ,5 mg haloperidol was injected twice .As of Day 2 ,thrice daily for 6 days .The scales of positive and negative syndrome scale (PANSS) and Pittsburg sleep quality index (PSQI) were assessed before and after treatment .And the neurotransmitter function parameters were detected by EFG before and after treatment .[Results]No significant difference existed in total cerebral pow‐er for 9 neurotransmitters before and after treatment ( P>0 .05) .After treatment ,the relative powers of norepi‐nephrine and vasomotor index were lower than those before treatment ( P<0 .05) .There were significant decrea‐ses in PANSS and PSQI before and after treatment ( P<0 .05) .[Conclusion] The mechanism of brief haloperidol therapy lies in that haloperidol decreases the function of norepinephrine .Capable of assessing the functions of mul‐tiple neurotransmitters ,EFG plays an important role in elucidating the neurobiochemical mechanisms of schizo‐phrenia ,antipsychotic drugs and monitoring efficacy .