中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
17期
132-134,135
,共4页
左心孟旦%心力衰竭%心脏手术%进展
左心孟旦%心力衰竭%心髒手術%進展
좌심맹단%심력쇠갈%심장수술%진전
levosimendan%heart failure%cardiac surgery%Progress
左西孟旦为钙离子增敏剂,通过肌钙蛋白C对钙离子的增敏作用来提高心肌收缩力,且不增加细胞内环磷腺苷和细胞内钙离子浓度。左西孟旦具有正性肌力作用但不提高细胞内钙离子浓度和心肌耗氧量,可降低危重症患者的死亡率,在心脏围手术期有应用价值。该文对左西孟旦的药理作用、药代动力学及在心衰患者围手术期应用进行综述,为其进一步临床使用提供参考。
左西孟旦為鈣離子增敏劑,通過肌鈣蛋白C對鈣離子的增敏作用來提高心肌收縮力,且不增加細胞內環燐腺苷和細胞內鈣離子濃度。左西孟旦具有正性肌力作用但不提高細胞內鈣離子濃度和心肌耗氧量,可降低危重癥患者的死亡率,在心髒圍手術期有應用價值。該文對左西孟旦的藥理作用、藥代動力學及在心衰患者圍手術期應用進行綜述,為其進一步臨床使用提供參攷。
좌서맹단위개리자증민제,통과기개단백C대개리자적증민작용래제고심기수축력,차불증가세포내배린선감화세포내개리자농도。좌서맹단구유정성기력작용단불제고세포내개리자농도화심기모양량,가강저위중증환자적사망솔,재심장위수술기유응용개치。해문대좌서맹단적약리작용、약대동역학급재심쇠환자위수술기응용진행종술,위기진일보림상사용제공삼고。
Levosimendan is a kind of calcium sensitizers. It imProves myocardial contractility by sensitization of troPonin C to calcium without increasing intracellular cAMP or intracellular calcium concentration. Levosimendan has a Positive inotroPic effect without increas-ing the intracellular calcium ion concentration and myocardial oxygen consumPtion, and can reduce mortality in critically ill Patients, has aPPlication value in the PerioPerative cardiac surgery Period. This review summarize the Pharmacology and Pharmacokinetics of levosi-mendan and aPPlication of levosimendan in Patients with heart failure in PerioPerative Period, in order to Provide reference for its further clinical aPPlication.