CAJ | 학술논문

目的：观察羟考酮联合帕瑞昔布钠对胃癌根治术后镇痛的效果及护理体会。方法将研究对象分为治疗组和对照组，各50例。治疗组经麻醉后给予帕瑞昔布钠40 mg，缓慢静脉注射羟考酮0.03 mg/kg，对照组在相同条件下静脉注射0.9％氯化钠注射液5 mL。结果治疗组患者术后24 h内的视觉模拟镇痛（VAS）评分均显著低于对照组( P＜0.05)，镇痛效果好；且术后恶心呕吐、腹部不适和嗜睡等不良反应的发生率明显低于对照组（ P＜0.05)；患者术后胃肠创伤愈合时间、住院时间及并发症比较，治疗组明显低于对照组( P＜0.05)。结论羟考酮联合帕瑞昔布钠用于胃癌根治术术后镇痛有很好的效果，且不良反应较少，能帮助患者术后及时恢复，值得临床推广。
목적：관찰간고동연합파서석포납대위암근치술후진통적효과급호리체회。방법장연구대상분위치료조화대조조，각50례。치료조경마취후급여파서석포납40 mg，완만정맥주사간고동0.03 mg/kg，대조조재상동조건하정맥주사0.9％록화납주사액5 mL。결과치료조환자술후24 h내적시각모의진통（VAS）평분균현저저우대조조( P＜0.05)，진통효과호；차술후악심구토、복부불괄화기수등불량반응적발생솔명현저우대조조（ P＜0.05)；환자술후위장창상유합시간、주원시간급병발증비교，치료조명현저우대조조( P＜0.05)。결론간고동연합파서석포납용우위암근치술술후진통유흔호적효과，차불량반응교소，능방조환자술후급시회복，치득림상추엄。
Objective To observe the clinical effect and nursing exPerience and of oxycodone combined with Parecoxib sodium for Post-oPerative analgesia after radical resection of gastric cancer. Methods The subjects were divided into the treatment grouP and the con-trol grouP, 50 cases in each grouP. The treatment grouP were administered Parecoxib sodium grouP 40 mg and slow intravenous injection of bolus oxycodone 0. 03 mg/kg after anesthesia,the control grouP were intravenously injected 0. 9% sodium chloride solution 5 mL under the same conditions. Results The VAS scores of the treatment grouP within 24 h were significantly lower than the control grouP ( P < 0. 05 ) and had good analgesic effect; and PostoPerative incidence of nausea and vomiting,abdominal discomfort and sleePiness were decreased more significantly comPared with the control grouP ( P < 0. 05 ); PostoPerative gastrointestinal trauma recovery time, hosPitalization time and mitigation of comPlications in the treatment grouP were significantly shorter than those of the control grouP ( P < 0. 05 ) . Conclusion Oxycodone combined with Parecoxib sodium for analgesia after radical surgery of gastric cancer had good aPPlication effect,less adverse reaction,can helP Patients recover timely,and is worthy of clinical aPPlication.