CAJ | 학술논문

目的探讨新疆维吾尔族和汉族寻常型天疱疮的临床特点和治疗方案.方法回顾性分析61例维吾尔族和汉族寻常型天疱疮住院患者的资料.结果 61例患者中,44例(72.13％)合并口腔和(或)外阴黏膜溃疡,49例(80.33％)尼氏征阳性,52例(85.25％)伴不同程度瘙痒,30例(49.18％)合并低蛋白血症.轻中型患者单用糖皮质激素疗效较好,重型患者联合免疫抑制剂或丙种球蛋白疗效较好.维吾尔族患者和汉族患者相比较,其黏膜受累、血细胞沉降率增快和低蛋白血症显著增加,差异有统计学意义(P＜0.05).结论 61例寻常型天疱疮患者中,维吾尔族重型患者所占比例高于汉族.
목적 탐토신강유오이족화한족심상형천포창적림상특점화치료방안.방법 회고성분석61례유오이족화한족심상형천포창주원환자적자료.결과 61례환자중,44례(72.13％)합병구강화(혹)외음점막궤양,49례(80.33％)니씨정양성,52례(85.25％)반불동정도소양,30례(49.18％)합병저단백혈증.경중형환자단용당피질격소료효교호,중형환자연합면역억제제혹병충구단백료효교호.유오이족환자화한족환자상비교,기점막수루、혈세포침강솔증쾌화저단백혈증현저증가,차이유통계학의의(P＜0.05).결론 61례심상형천포창환자중,유오이족중형환자소점비례고우한족.
Objective To assess clinical features of and treatment protocols for pemphigus vulgaris (PV) in patients of Han or Uygur nationality in Xinjiang Uygur Autonomous Region.Methods Clinical data were collected from 61 inpatients with PV of Han or Uygur nationality,and analyzed retrospectively.Results Of the 61 patients,44 (72.13％) had oral and/or vulval ulcer,49 (80.33％) positive Nikolsky's sign;52 (85.25％) suffered from different degrees of itching,and 30 (49.18％) from hypoproteinemia.Glucocorticoids alone are effective for mild to moderate PV,while immunosuppressive agents and gamma globulin should be combined to control severe PV.Compared with patients of Han nationality,those of Uygur nationality showed increased frequency of mucosal involvement,incidence of hypoproteinemia,and elevated blood sedimentation rate (all P ＜ 0.05).Conclusion In this study,the patients of Uygur nationality showed a higher proportion of severe PV cases compared with those of Han nationality.