CAJ | 학술논문

目的：比较甲硝唑栓、替硝唑栓、奥硝唑栓3种栓剂治疗滴虫性阴道炎的临床疗效和安全性。方法将180例滴虫性阴道炎患者随机分为3组，各60例。A组采用甲硝唑栓，B组采用替硝唑栓，C组采用奥硝唑栓，均阴道局部给药，疗程均为7 d。结果3组患者治疗后症状均有明显好转，治疗后症状改善情况C组优于A组和B组（ P＜0.05）。A组、B组和C组的总有效率分别为78.33％，91.67％和100.00％，与A组和B组比较，C组差异有统计学意义（ P＜0.05）。甲硝唑栓的药品不良反应发生率明显高于替硝唑栓和奥硝唑栓（ P＜0.05）。结论奥硝唑栓阴道局部给药治疗滴虫性阴道炎，安全有效，且优于甲硝唑栓和替硝唑栓，值得推广。
목적：비교갑초서전、체초서전、오초서전3충전제치료적충성음도염적림상료효화안전성。방법장180례적충성음도염환자수궤분위3조，각60례。A조채용갑초서전，B조채용체초서전，C조채용오초서전，균음도국부급약，료정균위7 d。결과3조환자치료후증상균유명현호전，치료후증상개선정황C조우우A조화B조（ P＜0.05）。A조、B조화C조적총유효솔분별위78.33％，91.67％화100.00％，여A조화B조비교，C조차이유통계학의의（ P＜0.05）。갑초서전적약품불량반응발생솔명현고우체초서전화오초서전（ P＜0.05）。결론오초서전음도국부급약치료적충성음도염，안전유효，차우우갑초서전화체초서전，치득추엄。
Objective To comPare the clinical efficacy and safety of three suPPositories ( metronidazole,tinidazole,ornidazole ) in treatment of trichomonas vaginitis. Methods 180 Patients with trichomonas vaginitis were divided into three grouPs randomly,60 cases in each grouP. Patients in grouP A,B and C were given metronidazole,tinidazole,ornidazole,resPectively. The course of treatment was all 7 d. Results After the treatment,the symPtoms of three grouPs were all obviously imProved ( C > A & B,P < 0. 05 ) . The total effective rates of the three grouPs were 78. 33%,91. 67% and 100. 00%,resPectively. ComPared with grouP A & B,the difference of grouP C was statistically significant ( P < 0. 05 ) . The adverse reaction rate of metronidazole suPPository was higher than that of tinidazole suPPository and ornidazole suPPository ( P < 0. 05 ) . Conclusion Ornidazole suPPository for toPical treatment of trichomonas vaginitis is safe and effective,and is worth of clinical Promotion.