CAJ | 학술논문

目的阐述食欲素的生理功能以及与瘦素和恶性肿瘤的相关性，对其在肿瘤治疗等方面的应用前景进行展望。方法回顾和研究近几年来国内外发表的有关食欲素的生理作用，与瘦素和恶性肿瘤相关性的中英文相关文献。结果食欲素不仅可参与调节能量代谢和摄食行为，还在睡眠-觉醒周期、应激、药物成瘾复吸、胰岛素分泌、胃酸分泌等方面有着非常重要的作用，且已有文献证实食欲素可影响恶性肿瘤患者的食欲和促进恶性肿瘤细胞的凋亡。结论食欲素在开发治疗糖尿病、药物成瘾和嗜睡症的新型药物及改善恶性肿瘤患者食欲和促进恶性肿瘤细胞凋亡方面具有应用前景。
목적천술식욕소적생리공능이급여수소화악성종류적상관성，대기재종류치료등방면적응용전경진행전망。방법회고화연구근궤년래국내외발표적유관식욕소적생리작용，여수소화악성종류상관성적중영문상관문헌。결과식욕소불부가삼여조절능량대사화섭식행위，환재수면-각성주기、응격、약물성은복흡、이도소분비、위산분비등방면유착비상중요적작용，차이유문헌증실식욕소가영향악성종류환자적식욕화촉진악성종류세포적조망。결론식욕소재개발치료당뇨병、약물성은화기수증적신형약물급개선악성종류환자식욕화촉진악성종류세포조망방면구유응용전경。
Objective To elaborate the physiological functions of orexin and the correlation between leptin and malignant tumor, in addition to look forward its application prospect in tumor.Methods We reviewed and researched the domestic and foreign published literature about the physiological function of orexin, and the relationship between leptin and malignant tumor.Results Orexin can not only be involved in the regulation of energy metabolism, feeding behavior, but also play a very important role in the sleep wake cycle, stress, drug addiction and relapse, insulin secretion, gastric acid secretion, and many studies have conifrmed that orexin can affect the appetite of patients with malignant tumor and promote the apoptosis of cancer cells.Conclusions Orexin has the application prospect in drug discovery for treating diabetes, drug addiction and narcolepsy, improving the poor quality of appetite in patients with malignant tumor and promoting the apoptosis of malignant tumor cells.