CAJ | 학술논문

目的：探讨非布索坦治疗痛风合并高尿酸血症患者的疗效。方法将痛风合并高尿酸血症患者150例分为A1组、A2组和B组，各50例。A1组服用40 mg/d非布索坦片，A2组服用80 mg/d非布索坦片，B组服用300 mg/d别嘌呤醇片，治疗时间均为24周。结果与治疗前相比，治疗10，24周后，3组患者血尿酸水平均显著降低（ P＜0.05），与B组患者相比，A1组和A2组患者的血尿酸水平均显著降低（ P＜0.05）；与A1组患者相比，A2组患者的血尿酸水平降低不显著（ P＞0.05）。3组患者的不良反应无明显差异（ P＞0.05）。结论非布索坦能有效降低痛风患者的血尿酸水平，80 mg/d剂量组血尿酸水平降低效果最好。
목적：탐토비포색탄치료통풍합병고뇨산혈증환자적료효。방법장통풍합병고뇨산혈증환자150례분위A1조、A2조화B조，각50례。A1조복용40 mg/d비포색탄편，A2조복용80 mg/d비포색탄편，B조복용300 mg/d별표령순편，치료시간균위24주。결과여치료전상비，치료10，24주후，3조환자혈뇨산수평균현저강저（ P＜0.05），여B조환자상비，A1조화A2조환자적혈뇨산수평균현저강저（ P＜0.05）；여A1조환자상비，A2조환자적혈뇨산수평강저불현저（ P＞0.05）。3조환자적불량반응무명현차이（ P＞0.05）。결론비포색탄능유효강저통풍환자적혈뇨산수평，80 mg/d제량조혈뇨산수평강저효과최호。
Objective To investigate the effect of febuxostat in treating Patients with gout combined with hyPeruricemia. Methods 150 Patients with gout and hyPeruricemia were selected and divided into grouP A1,grouP A2 and grouP B, 50 cases in each grouP. GrouP A1 took 40 mg/d of febuxostat tablets,grouP A2 took 80 mg/d of febuxostat tablets,grouP B took 300 mg/d alloPurinol tablets;all Patients were treated for 24 weeks. Results ComPared with before treatment,after treatment for 10,24 weeks,the serum uric acid levels of the three grouPs were significantly decreased( P < 0. 05). After treatment for 10,24 weeks,comPared with the Patients in grouP B, the serum uric acid level of Patients in A1 and A2 grouP were significantly decreased ( P < 0. 05);comPared with the Patients in grouP A1,the serum uric acid level of Patients in grouP A2 were not decreased significantly ( P > 0. 05 ). There were no significant difference between the three grouPs in adverse reactions ( P > 0. 05). Conclusion Febuxostat can effectively reduce the serum uric acid level in Patients with gout,and the uric acid level of Patients in the 80 mg/d febuxostat grouP were decreased best.