中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
17期
90-91
,共2页
进展期胃癌%围手术期%近期疗效%药品不良反应
進展期胃癌%圍手術期%近期療效%藥品不良反應
진전기위암%위수술기%근기료효%약품불량반응
advanced gastric cancer%PerioPerative Period%short-term effect%drug adverse reaction
目的：探讨多西他赛、奥沙利铂联合替吉奥（DOS）的化学治疗(简称化疗)方案对进展期胃癌患者围手术期的影响。方法将收治的进展期胃癌患者80例随机分为对照组和观察组，各40例。对照组给予表阿霉素、顺铂和5－氟尿嘧啶（ECF）方案，观察组给予DOS方案，3周为1个疗程，两组均治疗3个疗程后行手术治疗。结果观察组术中出血量以及术后并发症总发生率显著低于对照组（ P＜0.05）。观察组R0，R1切除率分别为62.50％和37.50％，显著高于对照组的55.00％和30.00％（ P＜0.05）；观察组R2切除率为0，显著低于对照组的15.00％（ P＜0.05）。观察组总有效率为62.50％，高于对照组的47.50％（ P＜0.05）。观察组总不良反应发生率明显低于对照组（ P＜0.05）。结论 DOS化疗方案对进展期胃癌患者围手术期具有一定积极影响，能显著减少术中出血量及术后并发症，且近期疗效好，不良反应相对较少。
目的：探討多西他賽、奧沙利鉑聯閤替吉奧（DOS）的化學治療(簡稱化療)方案對進展期胃癌患者圍手術期的影響。方法將收治的進展期胃癌患者80例隨機分為對照組和觀察組，各40例。對照組給予錶阿黴素、順鉑和5－氟尿嘧啶（ECF）方案，觀察組給予DOS方案，3週為1箇療程，兩組均治療3箇療程後行手術治療。結果觀察組術中齣血量以及術後併髮癥總髮生率顯著低于對照組（ P＜0.05）。觀察組R0，R1切除率分彆為62.50％和37.50％，顯著高于對照組的55.00％和30.00％（ P＜0.05）；觀察組R2切除率為0，顯著低于對照組的15.00％（ P＜0.05）。觀察組總有效率為62.50％，高于對照組的47.50％（ P＜0.05）。觀察組總不良反應髮生率明顯低于對照組（ P＜0.05）。結論 DOS化療方案對進展期胃癌患者圍手術期具有一定積極影響，能顯著減少術中齣血量及術後併髮癥，且近期療效好，不良反應相對較少。
목적：탐토다서타새、오사리박연합체길오（DOS）적화학치료(간칭화료)방안대진전기위암환자위수술기적영향。방법장수치적진전기위암환자80례수궤분위대조조화관찰조，각40례。대조조급여표아매소、순박화5－불뇨밀정（ECF）방안，관찰조급여DOS방안，3주위1개료정，량조균치료3개료정후행수술치료。결과관찰조술중출혈량이급술후병발증총발생솔현저저우대조조（ P＜0.05）。관찰조R0，R1절제솔분별위62.50％화37.50％，현저고우대조조적55.00％화30.00％（ P＜0.05）；관찰조R2절제솔위0，현저저우대조조적15.00％（ P＜0.05）。관찰조총유효솔위62.50％，고우대조조적47.50％（ P＜0.05）。관찰조총불량반응발생솔명현저우대조조（ P＜0.05）。결론 DOS화료방안대진전기위암환자위수술기구유일정적겁영향，능현저감소술중출혈량급술후병발증，차근기료효호，불량반응상대교소。
Objective To investigate the effect of DOS chemotheraPy in treating PerioPerative Patients with advanced gastric cancer. Methods 80 cases of Patients with advanced gastric cancer from June 2012 to January 2014 were randomly divided into the control grouP and the observation grouP, 40 cases in each grouP. The control grouP received ePirubicin, cisPlatin and ECF regimen, and the ob-servation grouP received DOS regimen. 1 treatment course was 3 weeks, and the Patients received surgery after 3 courses of treat-ment. Results The blood loss and the overall incidence of PostoPerative comPlications of the observation grouP were significantly lower than those of the control grouP ( P < 0. 05 ); the R0, R1 resection rates of the observation grouP were 62. 50% and 37. 50%, which were significantly higher than 55. 00% and 30. 00% of the control grouP ( P < 0. 05 );the R2 resection rate of the observation grouP was 0, which was significantly lower than 15. 00% of the control grouP ( P < 0. 05 ) . The total effective rate of the observation grouP was 62. 50%, which was significantly higher than 37. 50% of the control grouP ( P < 0. 05 ) . The total occurrence rate of adverse reac-tions of the observation grouP was significantly lower than the control grouP ( P < 0. 05 ) . Conclusion DOS chemotheraPy for PerioPera-tive Patients with advanced gastric cancer has certain Positive effect;it can significantly reduce blood loss and PostoPerative comPlica-tions in Patients with good short-term effect and relatively few adverse reactions.
