CAJ | 학술논문

目的：探讨国产拉坦前列腺素治疗老年难治性青光眼的疗效及安全性。方法86例老年难治性青光眼患者接受国产拉坦前列腺素滴眼液治疗。结果治疗1周后眼内压峰值及压差较治疗前显著下降（ P＜0.01），且随着治疗时间的延长呈下降趋势。患眼视力治疗后1，2，4周均较治疗前显著升高（ P＜0.01）。患眼视网膜中动脉血流收缩期峰值血流速度及舒张末期血流速度治疗后1周较治疗前显著升高，且随着治疗时间延长呈升高趋势（ P＜0.01），血管阻力指数治疗后1，2，4周均较治疗前显著降低（ P＜0.01）。86例患者出现眼部发红8例（9.39％）、轻度结膜一过性充血4例（4.65％）、眼痒3例（3.49％）、眼涩2例（2.32％）、眼睑皮疹1例（1.16％）。结论国产拉坦前列腺素能有效降低老年难治性青光眼患者的眼压，改善视力和视网膜中动脉血流，疗效显著，且不良反应轻，安全性高。
목적：탐토국산랍탄전렬선소치료노년난치성청광안적료효급안전성。방법86례노년난치성청광안환자접수국산랍탄전렬선소적안액치료。결과치료1주후안내압봉치급압차교치료전현저하강（ P＜0.01），차수착치료시간적연장정하강추세。환안시력치료후1，2，4주균교치료전현저승고（ P＜0.01）。환안시망막중동맥혈류수축기봉치혈류속도급서장말기혈류속도치료후1주교치료전현저승고，차수착치료시간연장정승고추세（ P＜0.01），혈관조력지수치료후1，2，4주균교치료전현저강저（ P＜0.01）。86례환자출현안부발홍8례（9.39％）、경도결막일과성충혈4례（4.65％）、안양3례（3.49％）、안삽2례（2.32％）、안검피진1례（1.16％）。결론국산랍탄전렬선소능유효강저노년난치성청광안환자적안압，개선시력화시망막중동맥혈류，료효현저，차불량반응경，안전성고。
Objective To exPlore the efficacy and safety of domestic LatanoProst for treating elder Patients with refractory glaucoma. Methods 86 elder Patients with refractory glaucoma were treated by domestic LatanoProst. Results The Peak value and difference of intraocular Pressure were significantly decreased after treatment of 1 week comPared with before treatment ( P < 0. 01),and showed downtrend during the treatment( P < 0. 01). The vision was increased after treatment of 1,2,4 weeks( P < 0. 01). The PSV and EDV was increased along with the Period of treatment,but the RI was decreased( P < 0. 01). There were 8 Patients(9. 39%)with eye redness,4 Patients(4. 65%)with mild hyPeremia of conjunctiva,3 Patients(3. 49%)with eye itching,2 Patients(2. 32%)with eye unsmooth,and 1 Patient(1. 16%)with eyelid rash. Conclusion The domestic LatanoProst can decrease the intraocular Pressure,imProve the vision and the blood of retina medium artery for elder Patients with refractory glaucoma effectively and safely and has few adverse reactions.