CAJ | 학술논문

S100A8和S100A9是S100蛋白家族中重要的成员,早期研究认为,S100A8和S100A9参与炎症反应,与机体固有免疫相关,并在调节肿瘤细胞的形成、浸润和转化中起着关键性的作用.然而,近年来研究表明,当机体处于某些特殊条件如伤口愈合、紫外线照射时,上皮细胞也分泌S100A8和S100A9,特别是在一些皮肤病中,这两种蛋白表达都有所上调.随着对S100A8和S100A9与皮肤病关系的进一步研究,可找到对这些疾病新的诊断和治疗方法.
S100A8화S100A9시S100단백가족중중요적성원,조기연구인위,S100A8화S100A9삼여염증반응,여궤체고유면역상관,병재조절종류세포적형성、침윤화전화중기착관건성적작용.연이,근년래연구표명,당궤체처우모사특수조건여상구유합、자외선조사시,상피세포야분비S100A8화S100A9,특별시재일사피부병중,저량충단백표체도유소상조.수착대S100A8화S100A9여피부병관계적진일보연구,가조도대저사질병신적진단화치료방법.
S100A8 and S100A9 are important members of the S100 protein family.It was previously deemed that S100A8 and S100A9 participated in inflammatory reactions,were associated with innate immunity,and played key roles in regulating tumor cell generation,infiltration and transformation.However,recent studies have suggested that when the human body is under some special conditions,such as wound healing and ultraviolet irradiation,epithelial cells are induced to secrete both S100A8 and S100A9 proteins,which are also up-regulated in some dermatoses.With further insight into the relationship between S100A8,S100A9 and dermatoses,new strategies will be developed for the diagnosis and treatment of these entities.