CAJ | 학술논문

兜甲蛋白是角质包膜的主要组成成分,对表皮的屏障功能起重要作用.该基因的表达调控受多个转录因子之间复杂的相互作用共同调控.兜甲蛋白基因突变可导致兜甲蛋白角皮症,突变体兜甲蛋白发生核易位干扰了角质形成细胞的终末分化,从而引起相应临床表型.兜甲蛋白在特应性皮炎和银屑病皮损内亦出现表达减少,其表达异常受相关细胞因子的影响.
두갑단백시각질포막적주요조성성분,대표피적병장공능기중요작용.해기인적표체조공수다개전록인자지간복잡적상호작용공동조공.두갑단백기인돌변가도치두갑단백각피증,돌변체두갑단백발생핵역위간우료각질형성세포적종말분화,종이인기상응림상표형.두갑단백재특응성피염화은설병피손내역출현표체감소,기표체이상수상관세포인자적영향.
Loricrin,as the major component of the cornified envelope,plays an important role in epidermal barrier function.The expression of loricrin gene is co-regulated by complex interactions between multiple transcription factors.Loricrin gene mutations can lead to loricrin keratoderma.Nuclear translocation of mutant loricrin can interfere with terminal differentiation of keratinocytes,and cause corresponding clinical phenotypes.In addition,the expression of loricrin is decreased in lesions of atopic dermatitis and psoriasis,which may be attributed to some cytokines.